Cited 1 times in
Antiretroviral genotypic resistance mutations in HIV-1 infected Korean patients with virologic failure
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김준명 | - |
dc.contributor.author | 진범식 | - |
dc.date.accessioned | 2015-04-24T17:43:07Z | - |
dc.date.available | 2015-04-24T17:43:07Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105936 | - |
dc.description.abstract | Resistance assays are useful in guiding decisions for patients experiencing virologic failure (VF) during highly-active antiretroviral therapy (HAART). We investigated antiretroviral resistance mutations in 41 Korean human immunodeficiency virus type 1 (HIV-1) infected patients with VF and observed immunologic/virologic response 6 months after HAART regimen change. Mean HAART duration prior to resistance assay was 45.3+/-27.5 months and commonly prescribed HAART regimens were zidovudine/lamivudine/nelfinavir (22.0%) and zidovudine/lamivudine/efavirenz (19.5%). Forty patients (97.6%) revealed intermediate to high-level resistance to equal or more than 2 antiretroviral drugs among prescribed HAART regimen. M184V/I mutation was observed in 36 patients (87.7%) followed by T215Y/F (41.5%) and M46I/L (34%). Six months after resistance assay and HAART regimen change, median CD4+ T cell count increased from 168 cells/microL (interquartile range [IQR], 62-253) to 276 cells/microL (IQR, 153-381) and log viral load decreased from 4.65 copies/mL (IQR, 4.18-5.00) to 1.91 copies/mL (IQR, 1.10-3.60) (P<0.001 for both values). the number of patients who accomplished viral load <400 copies/mL was 26 (63.4%) at 6 months follow-up. in conclusion, many Korean HIV-1 infected patients with VF are harboring strains with multiple resistance mutations and immunologic/virologic parameters are improved significantly after genotypic resistance assay and HAART regimen change. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1031~1037 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antiretroviral Therapy, Highly Active* | - |
dc.subject.MESH | Biological Assay/methods | - |
dc.subject.MESH | Biological Assay/utilization | - |
dc.subject.MESH | Drug Resistance, Viral/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | HIV Infections/drug therapy* | - |
dc.subject.MESH | HIV Infections/genetics | - |
dc.subject.MESH | HIV-1/genetics* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mutation* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Viral Load | - |
dc.subject.MESH | Young Adult | - |
dc.title | Antiretroviral genotypic resistance mutations in HIV-1 infected Korean patients with virologic failure | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Bum Sik Chin | - |
dc.contributor.googleauthor | Ju-Yeon Choi | - |
dc.contributor.googleauthor | Jin Young Choi | - |
dc.contributor.googleauthor | Gab Jung Kim | - |
dc.contributor.googleauthor | Mee-Kyung Kee | - |
dc.contributor.googleauthor | June Myung Kim | - |
dc.contributor.googleauthor | Sung Soon Kim | - |
dc.identifier.doi | 10.3346/jkms.2009.24.6.1031 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00953 | - |
dc.contributor.localId | A03981 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 19949656 | - |
dc.subject.keyword | HIV-1 | - |
dc.subject.keyword | Treatment Failure | - |
dc.subject.keyword | Drug Resistance | - |
dc.subject.keyword | Genotype | - |
dc.contributor.alternativeName | Kim, June Myung | - |
dc.contributor.alternativeName | Chin, Bum Sik | - |
dc.contributor.affiliatedAuthor | Kim, June Myung | - |
dc.contributor.affiliatedAuthor | Chin, Bum Sik | - |
dc.citation.volume | 24 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1031 | - |
dc.citation.endPage | 1037 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.24(6) : 1031-1037, 2009 | - |
dc.identifier.rimsid | 51454 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.