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Antiretroviral genotypic resistance mutations in HIV-1 infected Korean patients with virologic failure

DC Field Value Language
dc.contributor.author김준명-
dc.contributor.author진범식-
dc.date.accessioned2015-04-24T17:43:07Z-
dc.date.available2015-04-24T17:43:07Z-
dc.date.issued2009-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/105936-
dc.description.abstractResistance assays are useful in guiding decisions for patients experiencing virologic failure (VF) during highly-active antiretroviral therapy (HAART). We investigated antiretroviral resistance mutations in 41 Korean human immunodeficiency virus type 1 (HIV-1) infected patients with VF and observed immunologic/virologic response 6 months after HAART regimen change. Mean HAART duration prior to resistance assay was 45.3+/-27.5 months and commonly prescribed HAART regimens were zidovudine/lamivudine/nelfinavir (22.0%) and zidovudine/lamivudine/efavirenz (19.5%). Forty patients (97.6%) revealed intermediate to high-level resistance to equal or more than 2 antiretroviral drugs among prescribed HAART regimen. M184V/I mutation was observed in 36 patients (87.7%) followed by T215Y/F (41.5%) and M46I/L (34%). Six months after resistance assay and HAART regimen change, median CD4+ T cell count increased from 168 cells/microL (interquartile range [IQR], 62-253) to 276 cells/microL (IQR, 153-381) and log viral load decreased from 4.65 copies/mL (IQR, 4.18-5.00) to 1.91 copies/mL (IQR, 1.10-3.60) (P<0.001 for both values). the number of patients who accomplished viral load <400 copies/mL was 26 (63.4%) at 6 months follow-up. in conclusion, many Korean HIV-1 infected patients with VF are harboring strains with multiple resistance mutations and immunologic/virologic parameters are improved significantly after genotypic resistance assay and HAART regimen change.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1031~1037-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntiretroviral Therapy, Highly Active*-
dc.subject.MESHBiological Assay/methods-
dc.subject.MESHBiological Assay/utilization-
dc.subject.MESHDrug Resistance, Viral/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHHIV Infections/drug therapy*-
dc.subject.MESHHIV Infections/genetics-
dc.subject.MESHHIV-1/genetics*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMutation*-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHViral Load-
dc.subject.MESHYoung Adult-
dc.titleAntiretroviral genotypic resistance mutations in HIV-1 infected Korean patients with virologic failure-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorBum Sik Chin-
dc.contributor.googleauthorJu-Yeon Choi-
dc.contributor.googleauthorJin Young Choi-
dc.contributor.googleauthorGab Jung Kim-
dc.contributor.googleauthorMee-Kyung Kee-
dc.contributor.googleauthorJune Myung Kim-
dc.contributor.googleauthorSung Soon Kim-
dc.identifier.doi10.3346/jkms.2009.24.6.1031-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00953-
dc.contributor.localIdA03981-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid19949656-
dc.subject.keywordHIV-1-
dc.subject.keywordTreatment Failure-
dc.subject.keywordDrug Resistance-
dc.subject.keywordGenotype-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameChin, Bum Sik-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorChin, Bum Sik-
dc.citation.volume24-
dc.citation.number6-
dc.citation.startPage1031-
dc.citation.endPage1037-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.24(6) : 1031-1037, 2009-
dc.identifier.rimsid51454-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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