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Effect of E Coli Expressed Recombinant Human Bone Morphogenetic Protein-2(rhBMP-2) on Stem Cells for Periodontal Tissue Regeneration: A Preliminary Study

Authors
 Yoo-Jung Um  ;  Koo-Sung Cho  ;  Chang-Sung Kim 
Citation
 TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.6(1) : 346-352, 2009 
Journal Title
TISSUE ENGINEERING AND REGENERATIVE MEDICINE(조직공학과 재생의학)
ISSN
 1738-2696 
Issue Date
2009
Keywords
Stem cells ; bone morphogenetic protein ; periodontal regeneration
Abstract
Periodontal disease results in destruction of periodontal tissues(cementum, alveolar bone and periodontal
ligament) which may ultimately lead to tooth loss. To date, there is no ideal treatment approach in achieving optimal
periodontal tissue regeneration. Recruitment of progenitor cells to the site which could differentiate into cementoblasts,
osteoblasts and periodontal ligament-forming cells are needed and recently, using pluripotent stem cells isolated
from various tissues in conjugation with growth and differentiation factors have been presented to lead
periodontal tissue regeneration. This study evaluated the effect of E coli expressed recombinant human bone morphogenetic
protein-2(ErhBMP-2) to periodontal ligament stem cells(PDLSCs) and bone marrow stem
cells(BMSCs) on periodontal tissue regeneration. rhBMP-2 those expressed from E coli was treated on ex-vivo
expanded human BMSCs and PDLSCs to evaluate its regenerative effect in vivo and in vitro. Cementum, PDL-like
tissues and bone were regenerated in transplanting PDLSCs and BMSCs, respectively. There was enhanced tissue
regeneration when ErhBMP-2 was treated to PDLSCs, but not with BMSCs. Similar results were observed with in
vitro experiments. Though further studies are needed, the results suggest a possible treatment approach in combining
ErhBMP-2 and PDLSCs for periodontal tissues regeneration.
Files in This Item:
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Um, Yoo Jung(엄유정)
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105898
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