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Increased inflammation, reduced plasma phospholipid eicosapentaenoic acid and reduced antioxidant potential of treated hypertensive patients with metabolic syndrome

DC Field Value Language
dc.contributor.author박성하-
dc.contributor.author심지영-
dc.contributor.author이상학-
dc.contributor.author정남식-
dc.date.accessioned2015-04-24T17:39:47Z-
dc.date.available2015-04-24T17:39:47Z-
dc.date.issued2009-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/105828-
dc.description.abstractPURPOSE: In the present study, we tested whether the presence of metabolic syndrome (MetS) would worsen the features of inflammation, plasma omega 3 fatty acid levels and antioxidant potential in treated hypertensive patients. MATERIALS AND METHODS: TWO GROUPS WERE CLASSIFIED BY THE COMPONENTS OF METS: a reference group of treated hypertensive subjects: hypertension (HTN) group (n = 39) and with more than two additional MetS components: HTN with Mets group (n = 40). We further compared the parameters between HTN group and HTN with MetS group. RESULTS: The results showed that age (p < 0.001) and body mass index (BMI) (p < 0.001) were significantly different between HTN group and HTN with MetS group. Age- and BMI-adjusted total radical trapping antioxidant potential (TRAP) (p < 0.01) was significantly lower, whereas age- and BMI-adjusted CD (p < 0.05) and interleukin (IL) 6 (p < 0.05) were significantly higher in HTN with MetS group than in HTN group. Moreover, HTN with MetS group had significantly lower levels of age- and BMI-adjusted plasma phospholipid eicosapentaenoic acid (EPA) than HTN group (p < 0.05). On the other hand, the levels of age- and BMI-adjusted intracellular cell adhesion molecule-1 (ICAM-1), adiponectin and high molecular weight (HMW)-adiponectin were not significantly different between the groups. CONCLUSION: In conclusion, our results showed increased inflammatory marker, reduced antioxidant potential and EPA levels in treated hypertensive patients in the presence of MetS, suggesting the importance of changes of therapeutic lifestyle to modify the features of MetS.-
dc.description.statementOfResponsibilityopen-
dc.format.extent757~763-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdiponectin/blood-
dc.subject.MESHAge Factors-
dc.subject.MESHAntihypertensive Agents/therapeutic use-
dc.subject.MESHAntioxidants/metabolism*-
dc.subject.MESHBody Mass Index-
dc.subject.MESHEicosapentaenoic Acid/blood*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHypertension/blood*-
dc.subject.MESHHypertension/drug therapy-
dc.subject.MESHHypertension/immunology*-
dc.subject.MESHInflammation/immunology*-
dc.subject.MESHIntercellular Adhesion Molecule-1/blood-
dc.subject.MESHInterleukin-6/blood-
dc.subject.MESHMale-
dc.subject.MESHMetabolic Syndrome/blood-
dc.subject.MESHMetabolic Syndrome/complications*-
dc.subject.MESHMetabolic Syndrome/immunology-
dc.subject.MESHMiddle Aged-
dc.titleIncreased inflammation, reduced plasma phospholipid eicosapentaenoic acid and reduced antioxidant potential of treated hypertensive patients with metabolic syndrome-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorMin-Jeong Shin-
dc.contributor.googleauthorEugene Shim-
dc.contributor.googleauthorBorum Kang-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorSang-Hak Lee-
dc.contributor.googleauthorChi Young Shim-
dc.contributor.googleauthorEunju Park-
dc.contributor.googleauthorNamsik Chung-
dc.identifier.doi10.3349/ymj.2009.50.6.757-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01512-
dc.contributor.localIdA02213-
dc.contributor.localIdA03585-
dc.contributor.localIdA02833-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid20046414-
dc.subject.keywordMetabolic syndrome X-
dc.subject.keywordantioxidants-
dc.subject.keywordcytokines-
dc.subject.keywordeicosapentaenoic acid-
dc.subject.keywordhypertension-
dc.subject.keywordoxidative stress-
dc.contributor.alternativeNamePark, Sung Ha-
dc.contributor.alternativeNameShim, Chi Young-
dc.contributor.alternativeNameLee, Sang Hak-
dc.contributor.alternativeNameChung, Nam Sik-
dc.contributor.affiliatedAuthorPark, Sung Ha-
dc.contributor.affiliatedAuthorShim, Chi Young-
dc.contributor.affiliatedAuthorChung, Nam Sik-
dc.contributor.affiliatedAuthorLee, Snag Hak-
dc.citation.volume50-
dc.citation.number6-
dc.citation.startPage757-
dc.citation.endPage763-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.50(6) : 757-763, 2009-
dc.identifier.rimsid49872-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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