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IL-21 mediates suppressive effects via its induction of IL-10

Authors
 Rosanne Spolski  ;  Hyoung-Pyo Kim  ;  Wei Zhu  ;  David E. Levy  ;  Warren J. Leonard 
Citation
 JOURNAL OF IMMUNOLOGY, Vol.182(5) : 2859-2867, 2009 
Journal Title
JOURNAL OF IMMUNOLOGY
ISSN
 0022-1767 
Issue Date
2009
MeSH
Animals ; Cell Aggregation/immunology ; Cell Line ; Coculture Techniques ; Down-Regulation/genetics ; Down-Regulation/immunology* ; Humans ; Immunosuppression* ; Interleukin-10/biosynthesis* ; Interleukin-10/deficiency ; Interleukin-10/genetics* ; Interleukins/genetics ; Interleukins/physiology* ; Lymphocyte Activation/genetics ; Lymphocyte Activation/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Th1 Cells/immunology ; Th1 Cells/metabolism ; Transcriptional Activation/immunology*
Abstract
IL-21 is a pleiotropic cytokine that is required for normal Ig production. We previously showed that IL-21 was elevated in BXSB-Yaa mice with systemic lupus erythematosus. These mice also had elevated IL-10 levels, and we now show that IL-21 induces IL-10 mRNA and protein, suggesting unexpected immunosuppressive activities for IL-21. Indeed, Th1 priming with IL-21 leads to accumulation of cells with immunosuppressive activity, and IL-21 overexpression decreases specific Ab production after immunization in an IL-10-dependent fashion. Moreover, we show that IL-21 signaling is required for maximal induction of IL-10 by IL-6 or IL-27. Overall, our data indicate that IL-21 regulates immune responses at least in part by inducing IL-10 and reveal unanticipated immunosuppressive actions for this cytokine.
Files in This Item:
T200905240.pdf Download
DOI
10.4049/jimmunol.0802978
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyoung Pyo(김형표) ORCID logo https://orcid.org/0000-0003-1441-8822
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105788
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