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구강편평세포암종에서 Snail과 E-cadherin의 면역조직화학적 발현

DC FieldValueLanguage
dc.contributor.author김남희-
dc.contributor.author김현실-
dc.contributor.author육종인-
dc.contributor.author이상휘-
dc.date.accessioned2015-04-24T17:38:22Z-
dc.date.available2015-04-24T17:38:22Z-
dc.date.issued2009-
dc.identifier.issn1225-1577-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/105783-
dc.description.abstractEpithelial-mesenchymal transition (EMT) can play an important role in carcinogenesis of oral squamous cell carcinoma (OSCC). EMT is characterized by morphological and phenotypical change of epithelial cells into mesenchymal cells, and transcriptional repressor of E-cadherin, Snail is critical for EMT. In order to investigate the role of Snail and E-cadherin in OSCC, we analyzed the immunohistochemical pattern of Snail and E-cadherin in 18 OSCCs. The expression of Snail in the OSCC was increased whereas the expression of E-cadherin in the OSCC was decreased in comparison with those of normal oral mucosa, showing reverse correlation. Especially, the fibroblasts near the islands of OSCC showed the positivity of Snail, suggesting the reactive fibroblasts to the EMT of epithelial tumor cells. In metastatic squamous cell carcinoma in cervical lymph node, the positivity of Snail of tumor cells was higher than that of primary OSCC. We concluded that the increased Snail expression and the decreased E-cadherin expression were involved in the progression, invasion and metastasis of OSCC.-
dc.description.statementOfResponsibilityopen-
dc.format.extent37~45-
dc.relation.isPartOfKorean Journal of Oral and Maxillofacial Pathology-
dc.relation.isPartOf대한구강악안면병리학회지-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title구강편평세포암종에서 Snail과 E-cadherin의 면역조직화학적 발현-
dc.title.alternativeThe Immunohistochemical Expression of Snail and E-cadherin in Oral Squamous Cell Carcinoma-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentOral Cancer Research Institute (구강종양연구소)-
dc.contributor.googleauthor유미현-
dc.contributor.googleauthor육종인-
dc.contributor.googleauthor김남희-
dc.contributor.googleauthor고현석-
dc.contributor.googleauthor백정미-
dc.contributor.googleauthor박정국-
dc.contributor.googleauthor이상휘-
dc.contributor.googleauthor김현실-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00360-
dc.contributor.localIdA01121-
dc.contributor.localIdA02536-
dc.contributor.localIdA02839-
dc.relation.journalcodeJ02084-
dc.contributor.alternativeNameKim, Nam Hee-
dc.contributor.alternativeNameKim, Hyun Sil-
dc.contributor.alternativeNameYook, Jong In-
dc.contributor.alternativeNameLee, Sang Hwy-
dc.contributor.affiliatedAuthorKim, Nam Hee-
dc.contributor.affiliatedAuthorKim, Hyun Sil-
dc.contributor.affiliatedAuthorYook, Jong In-
dc.contributor.affiliatedAuthorLee, Sang Hwy-
dc.citation.volume33-
dc.citation.number1-
dc.citation.startPage37-
dc.citation.endPage45-
dc.identifier.bibliographicCitationKorean Journal of Oral and Maxillofacial Pathology (대한구강악안면병리학회지), Vol.33(1) : 37-45, 2009-
Appears in Collections:
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers

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