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Performance of the tuberculin skin test and interferon-gamma release assay for detection of tuberculosis infection in immunocompromised patients in a BCG-vaccinated population.
DC Field | Value | Language |
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dc.contributor.author | 장준 | - |
dc.contributor.author | 정지예 | - |
dc.contributor.author | 강영애 | - |
dc.contributor.author | 김세규 | - |
dc.contributor.author | 김영삼 | - |
dc.contributor.author | 김은영 | - |
dc.contributor.author | 문진욱 | - |
dc.contributor.author | 박무석 | - |
dc.contributor.author | 박병훈 | - |
dc.contributor.author | 손지영 | - |
dc.contributor.author | 윤여운 | - |
dc.contributor.author | 이경종 | - |
dc.contributor.author | 임주은 | - |
dc.date.accessioned | 2015-04-24T17:36:57Z | - |
dc.date.available | 2015-04-24T17:36:57Z | - |
dc.date.issued | 2009 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105738 | - |
dc.description.abstract | BACKGROUND: Interferon-gamma release assay (IGRA) may improve diagnostic accuracy for latent tuberculosis infection (LTBI). This study compared the performance of the tuberculin skin test (TST) with that of IGRA for the diagnosis of LTBI in immunocompromised patients in an intermediate TB burden country where BCG vaccination is mandatory. METHODS: We conducted a retrospective observational study of patients given the TST and an IGRA, the QuantiFERON-TB Gold In-Tube (QFT-IT), at Severance Hospital, a tertiary hospital in South Korea, from December 2006 to May 2009. RESULTS: Of 211 patients who underwent TST and QFT-IT testing, 117 (55%) were classified as immunocompromised. Significantly fewer immunocompromised than immunocompetent patients had positive TST results (10.3% vs. 27.7%, p 0.001), whereas the percentage of positive QFT-IT results was comparable for both groups (21.4% vs. 25.5%). However, indeterminate QFT-IT results were more frequent in immunocompromised than immunocompetent patients (21.4% vs. 9.6%, p 0.021). Agreement between the TST and QFT-IT was fair for the immunocompromised group (kappa = 0.38), but moderate agreement was observed for the immunocompetent group (kappa = 0.57). Indeterminate QFT-IT results were associated with anaemia, lymphocytopenia, hypoproteinemia, and hypoalbuminemia. CONCLUSION: In immunocompromised patients, the QFT-IT may be more sensitive than the TST for detection of LTBI, but it resulted in a considerable proportion of indeterminate results. Therefore, both tests may maximise the efficacy of screening for LTBI in immunocompromised patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 207 | - |
dc.relation.isPartOf | BMC INFECTIOUS DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | BCG Vaccine/administration & dosage | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunocompromised Host* | - |
dc.subject.MESH | Interferon-gamma/blood* | - |
dc.subject.MESH | Latent Tuberculosis/diagnosis* | - |
dc.subject.MESH | Latent Tuberculosis/epidemiology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Tuberculin Test* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Performance of the tuberculin skin test and interferon-gamma release assay for detection of tuberculosis infection in immunocompromised patients in a BCG-vaccinated population. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Eun Young Kim | - |
dc.contributor.googleauthor | Ju Eun Lim | - |
dc.contributor.googleauthor | Ji Ye Jung | - |
dc.contributor.googleauthor | Ji Young Son | - |
dc.contributor.googleauthor | Kyung Jong Lee | - |
dc.contributor.googleauthor | Yoe Wun Yoon | - |
dc.contributor.googleauthor | Byung Hoon Park | - |
dc.contributor.googleauthor | Jin Wook Moon | - |
dc.contributor.googleauthor | Moo Suk Park | - |
dc.contributor.googleauthor | Young Sam Kim | - |
dc.contributor.googleauthor | Se Kyu Kim | - |
dc.contributor.googleauthor | Joon Chang | - |
dc.contributor.googleauthor | Young Ae Kang | - |
dc.identifier.doi | 10.1186/1471-2334-9-207 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03472 | - |
dc.contributor.localId | A03735 | - |
dc.contributor.localId | A00057 | - |
dc.contributor.localId | A00602 | - |
dc.contributor.localId | A00707 | - |
dc.contributor.localId | A01387 | - |
dc.contributor.localId | A01457 | - |
dc.contributor.localId | A01478 | - |
dc.contributor.localId | A01996 | - |
dc.contributor.localId | A02575 | - |
dc.contributor.localId | A03407 | - |
dc.contributor.localId | A00811 | - |
dc.contributor.localId | A02654 | - |
dc.relation.journalcode | J00360 | - |
dc.identifier.eissn | 1471-2334 | - |
dc.identifier.pmid | 20003535 | - |
dc.subject.keyword | Immunocompromised Patient | - |
dc.subject.keyword | Tuberculin Skin Test | - |
dc.subject.keyword | Indeterminate Result | - |
dc.subject.keyword | Tuberculin Skin Test Result | - |
dc.subject.keyword | Advanced Liver Cirrhosis | - |
dc.contributor.alternativeName | Chang, Joon | - |
dc.contributor.alternativeName | Jung, Ji Ye | - |
dc.contributor.alternativeName | Kang, Young Ae | - |
dc.contributor.alternativeName | Kim, Se Kyu | - |
dc.contributor.alternativeName | Kim, Young Sam | - |
dc.contributor.alternativeName | Kim, Eun Young | - |
dc.contributor.alternativeName | Moon, Jin Wook | - |
dc.contributor.alternativeName | Park, Moo Suk | - |
dc.contributor.alternativeName | Park, Byung Hoon | - |
dc.contributor.alternativeName | Son, Ji Young | - |
dc.contributor.alternativeName | Yoon, Yoe Wun | - |
dc.contributor.alternativeName | Lee, Kyung Jong | - |
dc.contributor.alternativeName | Lim, Ju Eun | - |
dc.contributor.affiliatedAuthor | Chang, Joon | - |
dc.contributor.affiliatedAuthor | Jung, Ji Ye | - |
dc.contributor.affiliatedAuthor | Kang, Young Ae | - |
dc.contributor.affiliatedAuthor | Kim, Se Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Young Sam | - |
dc.contributor.affiliatedAuthor | Moon, Jin Wook | - |
dc.contributor.affiliatedAuthor | Park, Moo Suk | - |
dc.contributor.affiliatedAuthor | Park, Byung Hoon | - |
dc.contributor.affiliatedAuthor | Son, Ji Young | - |
dc.contributor.affiliatedAuthor | Yoon, Yoe Wun | - |
dc.contributor.affiliatedAuthor | Lim, Ju Eun | - |
dc.contributor.affiliatedAuthor | Kim, Eun Young | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Jong | - |
dc.citation.volume | 9 | - |
dc.citation.startPage | 207 | - |
dc.identifier.bibliographicCitation | BMC INFECTIOUS DISEASES, Vol.9 : 207, 2009 | - |
dc.identifier.rimsid | 43256 | - |
dc.type.rims | ART | - |
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