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Risk factors and dose-effect relationship for mandibular osteoradionecrosis in oral and oropharyngeal cancer patients

DC Field Value Language
dc.contributor.author금기창-
dc.contributor.author금웅섭-
dc.contributor.author김귀언-
dc.contributor.author김용배-
dc.contributor.author이익재-
dc.contributor.author이창걸-
dc.contributor.author차인호-
dc.contributor.author최은창-
dc.date.accessioned2015-04-24T17:33:43Z-
dc.date.available2015-04-24T17:33:43Z-
dc.date.issued2009-
dc.identifier.issn0360-3016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/105634-
dc.description.abstractPURPOSE: To analyze risk factors and the dose-effect relationship for osteoradionecrosis (ORN) of the mandible after radiotherapy of oral and oropharyngeal cancers. MATERIALS and METHODS: One-hundred ninety-eight patients with oral (45%) and oropharyngeal cancer (55%) who had received external radiotherapy between 1990 and 2000 were retrospectively reviewed. All patients had a dental evaluation before radiotherapy. the median radiation dose was 60 Gy (range, 16-75 Gy), and the median biologically effective dose for late effects (BED(late)) in bone was 114 Gy(2) (range, 30-167 Gy(2)). RESULTS: the frequency of ORN was 13 patients (6.6%). Among patients with mandibular surgery, eight had ORN at the surgical site. Among patients without mandibular surgery, five patients had ORN on the molar area of the mandible. the median time to ORN was 22 months (range, 1-69 months). Univariate analysis revealed that mandibular surgery and Co-60 were significant risk factors for ORN (p = 0.01 and 0.04, respectively). in multivariate analysis, mandibular surgery was the most important factor (p = 0.001). High radiation doses over BED 102.6 Gy(2) (conventional dose of 54 Gy at 1.8 Gy/fraction) were also a significant factor for ORN (p = 0.008) and showed a positive dose-effect relationship in logistic regression (p = 0.04) for patients who had undergone mandibular surgery. CONCLUSIONS: Mandibular surgery was the most significant risk factor for ORN of mandible in oral and oropharyngeal cancers patients. A BED of 102.6 Gy(2) or higher to the mandible also significantly increases the risk of ORN.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1084~1091-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAnalysis of Variance-
dc.subject.MESHDose-Response Relationship, Radiation-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMandible/surgery-
dc.subject.MESHMandibular Diseases/etiology*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMouth Neoplasms/radiotherapy*-
dc.subject.MESHMouth Neoplasms/surgery-
dc.subject.MESHOropharyngeal Neoplasms/radiotherapy*-
dc.subject.MESHOropharyngeal Neoplasms/surgery-
dc.subject.MESHOsteoradionecrosis/etiology*-
dc.subject.MESHPostoperative Complications-
dc.subject.MESHRadiotherapy Dosage-
dc.subject.MESHRegression Analysis-
dc.subject.MESHRelative Biological Effectiveness-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHYoung Adult-
dc.titleRisk factors and dose-effect relationship for mandibular osteoradionecrosis in oral and oropharyngeal cancer patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학)-
dc.contributor.googleauthorIK JAE LEE-
dc.contributor.googleauthorWOONG SUB KOOM-
dc.contributor.googleauthorCHANG GEOL LEE-
dc.contributor.googleauthorYONG BAE KIM-
dc.contributor.googleauthorSEI WHAN YOO-
dc.contributor.googleauthorKI CHANG KEUM-
dc.contributor.googleauthorGWI EON KIM-
dc.contributor.googleauthorEUN CHANG CHOI-
dc.contributor.googleauthorIN HO CHA-
dc.identifier.doi10.1016/j.ijrobp.2008.12.052-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00272-
dc.contributor.localIdA00273-
dc.contributor.localIdA00321-
dc.contributor.localIdA03055-
dc.contributor.localIdA03240-
dc.contributor.localIdA04161-
dc.contributor.localIdA00744-
dc.contributor.localIdA04002-
dc.relation.journalcodeJ01157-
dc.identifier.eissn1879-355X-
dc.identifier.pmid19327914-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0360301609000108-
dc.contributor.alternativeNameKeum, Ki Chang-
dc.contributor.alternativeNameKoom, Woong Sub-
dc.contributor.alternativeNameKim, Gwi Eon-
dc.contributor.alternativeNameKim, Yong Bae-
dc.contributor.alternativeNameLee, Ik Jae-
dc.contributor.alternativeNameLee, Chang Geol-
dc.contributor.alternativeNameCha, In Ho-
dc.contributor.alternativeNameChoi, Eun Chang-
dc.contributor.affiliatedAuthorKeum, Ki Chang-
dc.contributor.affiliatedAuthorKoom, Woong Sub-
dc.contributor.affiliatedAuthorKim, Gwi Eon-
dc.contributor.affiliatedAuthorLee, Ik Jae-
dc.contributor.affiliatedAuthorLee, Chang Geol-
dc.contributor.affiliatedAuthorChoi, Eun Chang-
dc.contributor.affiliatedAuthorKim, Yong Bae-
dc.contributor.affiliatedAuthorCha, In Ho-
dc.citation.volume75-
dc.citation.number4-
dc.citation.startPage1084-
dc.citation.endPage1091-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.75(4) : 1084-1091, 2009-
dc.identifier.rimsid40930-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers

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