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Tumor heterogeneity of FIGO stage III carcinoma of the uterine cervix

DC Field Value Language
dc.contributor.author김귀언-
dc.contributor.author김성훈-
dc.contributor.author김영태-
dc.contributor.author김용배-
dc.contributor.author서창옥-
dc.contributor.author이익재-
dc.date.accessioned2015-04-24T17:30:47Z-
dc.date.available2015-04-24T17:30:47Z-
dc.date.issued2009-
dc.identifier.issn0360-3016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/105540-
dc.description.abstractPURPOSE: The purpose of this study was to analyze tumor heterogeneity based on tumor extent and suggest reappraisal of the system of the International Federation of Gynecology and Obstetrics (FIGO) for Stage III carcinoma of the uterine cervix from a radiotherapeutic viewpoint. METHODS AND MATERIALS: Between 1986 and 2004, 407 patients with FIGO Stage III (FIGO Stage IIIa in 19 and IIIb in 388) were treated with external beam radiotherapy (RT) and high-dose rate brachytherapy. All patients were reviewed with respect to tumor extent. Patterns of failure and survival parameters were analyzed by use of the chi(2) test and Kaplan-Meier method. RESULTS: The complete response rate was 79.6%, and the 5-year overall survival rates for Stage IIIa and Stage IIIb carcinoma of the cervix were 82.1% and 54.8%, respectively. To determine which parameters of tumor extent had an influence on prognosis for Stage IIIb patients, pelvic wall (PW) extension and hydronephrosis (HD) retained significance on multivariate analysis. Stage IIIb patients were divided into three subgroups according to PW extension and HD: low risk (unilateral PW extension without HD), intermediate risk (HD without PW extension or bilateral PW extension without HD), and high risk (unilateral or bilateral PW extension with HD). The high-risk group had a remarkably low complete response rate, high locoregional failure rate, and low 5-year survival rate compared with the intermediate- and low-risk groups. CONCLUSIONS: FIGO Stage III carcinoma of the cervix covers considerably heterogeneous subgroups according to tumor extent. Before initiation of treatment, we suggest that physicians determine a tailored treatment policy based on tumor heterogeneity for each Stage III patient-
dc.description.statementOfResponsibilityopen-
dc.format.extent1323~1328-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/mortality-
dc.subject.MESHAdenocarcinoma/pathology-
dc.subject.MESHAdenocarcinoma/radiotherapy-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBrachytherapy/methods-
dc.subject.MESHCarcinoma/mortality-
dc.subject.MESHCarcinoma/pathology*-
dc.subject.MESHCarcinoma/radiotherapy-
dc.subject.MESHCarcinoma, Large Cell/mortality-
dc.subject.MESHCarcinoma, Large Cell/pathology-
dc.subject.MESHCarcinoma, Large Cell/radiotherapy-
dc.subject.MESHCarcinoma, Squamous Cell/mortality-
dc.subject.MESHCarcinoma, Squamous Cell/pathology-
dc.subject.MESHCarcinoma, Squamous Cell/radiotherapy-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging/methods*-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHTumorBurden-
dc.subject.MESHUterineCervicalNeoplasms/mortality-
dc.subject.MESHUterineCervicalNeoplasms/pathology*-
dc.subject.MESHUterineCervicalNeoplasms/radiotherapy-
dc.titleTumor heterogeneity of FIGO stage III carcinoma of the uterine cervix-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics & Gynecology (산부인과학)-
dc.contributor.googleauthorYONG BAE KIM-
dc.contributor.googleauthorIK JAE LEE-
dc.contributor.googleauthorSONG YIH KIM-
dc.contributor.googleauthorJUN WON KIM-
dc.contributor.googleauthorHONG IN YOON-
dc.contributor.googleauthorSANG WUN KIM-
dc.contributor.googleauthorSUNGHOON KIM-
dc.contributor.googleauthorYOUNG TAE KIM-
dc.contributor.googleauthorCHANG OK SUH-
dc.contributor.googleauthorGWI EON KIM-
dc.identifier.doi10.1016/j.ijrobp.2008.12.081-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00744-
dc.contributor.localIdA00595-
dc.contributor.localIdA00321-
dc.contributor.localIdA00729-
dc.contributor.localIdA01919-
dc.contributor.localIdA03055-
dc.relation.journalcodeJ01157-
dc.identifier.eissn1879-355X-
dc.identifier.pmid19467800-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0360301609002065-
dc.contributor.alternativeNameKim, Gwi Eon-
dc.contributor.alternativeNameKim, Sung Hoon-
dc.contributor.alternativeNameKim, Young Tae-
dc.contributor.alternativeNameKim, Yong Bae-
dc.contributor.alternativeNameSuh, Chang Ok-
dc.contributor.alternativeNameLee, Ik Jae-
dc.contributor.affiliatedAuthorKim, Yong Bae-
dc.contributor.affiliatedAuthorKim, Sung Hoon-
dc.contributor.affiliatedAuthorKim, Gwi Eon-
dc.contributor.affiliatedAuthorKim, Young Tae-
dc.contributor.affiliatedAuthorSuh, Chang Ok-
dc.contributor.affiliatedAuthorLee, Ik Jae-
dc.citation.volume75-
dc.citation.number5-
dc.citation.startPage1323-
dc.citation.endPage1328-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.75(5) : 1323-1328, 2009-
dc.identifier.rimsid44340-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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