Colorectal Neoplasm in Asymptomatic Average-risk Koreans: The KASID Prospective Multicenter Colonoscopy Survey
Authors
Hye-Won Park ; Jeong-Sik Byeon ; Suk-Kyun Yang ; Hyun Soo Kim ; Won Ho Kim ; Tae Il Kim ; Dong
Il Park ; Young-Ho Kim ; Hyo Jong Kim ; Moon Sung Lee ; Il-Kwon Chung ; Sung-Ae Jung ; Yoon Tae
Jeen ; Jai Hyun Choi ; Hwang Choi ; Kyu Yong Choi ; Dong Soo Han ; Jae Suk Song
Prevalence ; Colonoscopy ; Colorectal neoplasms Korea ; Mass screening
Abstract
BACKGROUND/AIMS: The incidence of colorectal cancer is increasing in Korea, but the epidemiology of colorectal neoplasm is not clearly defined. We aimed to elucidate the prevalence of colorectal neoplasm in average-risk Koreans and explore the underlying risk factors.
METHODS: A large-scale, multicenter, prospective study was conducted. Of the 19,460 subjects who underwent colonoscopy at 11 university hospitals, we analyzed 3,951 consecutive asymptomatic adults with no risk factors for colorectal cancer.
RESULTS: The subjects were aged 52.1+/-11.6 years (mean+/-SD) and 60.1% of them were men. The prevalences of colorectal neoplasm and advanced neoplasm were 33.3% and 2.2%, respectively. The prevalence of a neoplasm increased with age (trend: p<0.001) and was higher in males (p<0.001). The prevalence of a proximal neoplasm was higher in subjects with a distal neoplasm than in those without a distal neoplasm (11.9% vs. 5.4%, p<0.001). However, 150 (52.1%) of the 288 subjects with a proximal neoplasm had no distal neoplasm.
CONCLUSIONS: The overall prevalence of colorectal neoplasm in asymptomatic average-risk Koreans is comparable with that in Western countries. Being male and older are associated with a higher risk of colorectal neoplasm. Over half of proximal neoplasms are not associated with any distal sentinel lesions.