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병리학적 병기 Ia기 비소세포폐암 환자에서 완전절제술 후 사망의 원인에 따른 위험인자 분석

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dc.contributor.author김대준-
dc.contributor.author박인규-
dc.contributor.author정경영-
dc.date.accessioned2015-04-24T17:27:51Z-
dc.date.available2015-04-24T17:27:51Z-
dc.date.issued2009-
dc.identifier.issn2233-601X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/105447-
dc.description.abstractBackground: Lobectomy and more extended anatomic resection are regarded as standard treatment for stage Ia non-small cell lung cancer, but approximately 15∼40% of patients suffer from treatment failures such as cancer recurrence or death. The authors analyzed types and causes of treatment failures in surgically treated cases of stage Ia non small cell lung cancer. Material and Method: We retrospectively reviewed the medical records of 156 patients who had undergone complete resection for stage Ia NSCLC between Jan 1992 and Aug 2005. Patients were divided into two different treatment failure groups: cancer-related deaths and non-cancer-related deaths. Risk factors were analyzed in each group by the Kaplan-Meyer survival method and the Cox proportional hazard model. Result: Among the 156 patients, 93 were males; the mean age was 61. The median follow-up period was 33.8 months. The 5 year survival rate was 87.6%. Microscopic lympho-vascular permeation was reported in 10 patients. Recurrence was reported in 19 patients and 12 patients died due to recurrent lung cancer. Noncancer related deaths occurred in 16 patients. Risk factors for cancer recurrence and cancer related death were microscopic lympho-vascular permeation (HR=6.81, p=0.007, HR=7.81, p<0.001); for non-cancer related death, risk factors were pneumonectomy (HR=25.92, p=0.001) and postoperative cardiopulmonary complications (HR=29.67, p=0.002). Conclusion: After complete resection of stage Ia non small cell lung cancer patients, mortality includes not only cancer related deaths but also cancer unrelated deaths. Adjuvant chemotherapy is advised for patients who show microscopic lympho-vascular permeation, which is a risk factor for recurrence and for cancer related death. Patients who had pneumonectomy or who suffered from cardiac or respiratory complications need meticulous care in order to reduce comorbidity-induced death.-
dc.description.statementOfResponsibilityopen-
dc.format.extent725~731-
dc.relation.isPartOfKorean Journal of Thoracic and Cardiovascular Surgery (대한흉부외과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title병리학적 병기 Ia기 비소세포폐암 환자에서 완전절제술 후 사망의 원인에 따른 위험인자 분석-
dc.title.alternativeCause-specific Analysis of Risk Factors in Completely Resected Pathologic Stage Ia Non-small Cell Lung Cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Thoracic & Cardiovascular Surgery (흉부외과학)-
dc.contributor.googleauthor박성용-
dc.contributor.googleauthor박인규-
dc.contributor.googleauthor변천성-
dc.contributor.googleauthor이창영-
dc.contributor.googleauthor배미경-
dc.contributor.googleauthor김대준-
dc.contributor.googleauthor정경영-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00368-
dc.contributor.localIdA01625-
dc.contributor.localIdA03571-
dc.relation.journalcodeJ02127-
dc.subject.keywordLung neoplasm-
dc.subject.keywordPostoperative care-
dc.subject.keywordNeoplasm recurrence-
dc.contributor.alternativeNameKim, Dae Joon-
dc.contributor.alternativeNamePark, In Kyu-
dc.contributor.alternativeNameChung, Kyung Young-
dc.contributor.affiliatedAuthorKim, Dae Joon-
dc.contributor.affiliatedAuthorPark, In Kyu-
dc.contributor.affiliatedAuthorChung, Kyung Young-
dc.citation.volume42-
dc.citation.number6-
dc.citation.startPage725-
dc.citation.endPage731-
dc.identifier.bibliographicCitationKorean Journal of Thoracic and Cardiovascular Surgery (대한흉부외과학회지), Vol.42(6) : 725-731, 2009-
dc.identifier.rimsid51699-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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