Cited 12 times in
Therapy-related myelodysplastic syndrome with der(17)t(12;17)(q13;p13) as a new recurrent cytogenetic abnormality after treatment for chronic lymphocytic leukemia
DC Field | Value | Language |
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dc.contributor.author | 송재우 | - |
dc.contributor.author | 정준원 | - |
dc.contributor.author | 최종락 | - |
dc.date.accessioned | 2015-04-24T17:27:45Z | - |
dc.date.available | 2015-04-24T17:27:45Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0145-2126 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105444 | - |
dc.description.abstract | A 54-year-old male presented to our hospital for evaluation of peripheral lymphocytosis. He was initially diagnosed with chronic lymphocytic leukemia (CLL) and treated with six cycles of fludarabine, cyclophosphamide, and rituximab chemotherapy. Therapy-related myelodysplastic syndrome (t-MDS) was suspected approximately 2 years later; in addition, complex karyotypic abnormalities including 5q deletion, monosomy 7, and der(17)t(12;17)(q13;p13) were found repeatedly in the patient's chromosome studies. The chromosomal abnormality der(17)t(12;17)(q13;p13) is very rare in hematologic malignancies, and has been reported in only two patients with therapy-related acute myeloid leukemia (t-AML). To our knowledge, this is the first report of t-MDS with der(17)t(12;17)(q13;p13) after treatment for CLL. In addition, we suggest that der(17)t(12;17)(q13;p13) should be considered a new recurrent, nonrandom chromosomal abnormality in patients with t-MDS/AML | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1001~1004 | - |
dc.relation.isPartOf | LEUKEMIA RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/adverse effects* | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/therapeutic use | - |
dc.subject.MESH | Chromosome Deletion | - |
dc.subject.MESH | Chromosomes, Human, Pair 12/genetics* | - |
dc.subject.MESH | Chromosomes, Human, Pair 17/genetics* | - |
dc.subject.MESH | Cytogenetic Analysis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | In Situ Hybridization, Fluorescence | - |
dc.subject.MESH | Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy* | - |
dc.subject.MESH | Leukemia, Lymphocytic, Chronic, B-Cell/genetics | - |
dc.subject.MESH | Leukemia, Lymphocytic, Chronic, B-Cell/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Monosomy | - |
dc.subject.MESH | Myelodysplastic Syndromes/chemically induced* | - |
dc.subject.MESH | Myelodysplastic Syndromes/genetics* | - |
dc.subject.MESH | Translocation, Genetic/genetics* | - |
dc.title | Therapy-related myelodysplastic syndrome with der(17)t(12;17)(q13;p13) as a new recurrent cytogenetic abnormality after treatment for chronic lymphocytic leukemia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Tae Sung Park | - |
dc.contributor.googleauthor | June-Won Cheong | - |
dc.contributor.googleauthor | Jaewoo Song | - |
dc.contributor.googleauthor | Jong Rak Choi | - |
dc.identifier.doi | 10.1016/j.leukres.2008.11.025 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02054 | - |
dc.contributor.localId | A03729 | - |
dc.contributor.localId | A04182 | - |
dc.relation.journalcode | J02166 | - |
dc.identifier.eissn | 1873-5835 | - |
dc.identifier.pmid | 19155067 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0145212608005262 | - |
dc.subject.keyword | CLL | - |
dc.subject.keyword | Fludarabine | - |
dc.subject.keyword | Cyclophosphamide | - |
dc.subject.keyword | Rituximab | - |
dc.subject.keyword | t-MDS | - |
dc.contributor.alternativeName | Song, Jae Woo | - |
dc.contributor.alternativeName | Cheong, June Won | - |
dc.contributor.alternativeName | Choi, Jong Rak | - |
dc.contributor.affiliatedAuthor | Song, Jae Woo | - |
dc.contributor.affiliatedAuthor | Cheong, June-Won | - |
dc.contributor.affiliatedAuthor | Choi, Jong Rak | - |
dc.citation.volume | 33 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1001 | - |
dc.citation.endPage | 1004 | - |
dc.identifier.bibliographicCitation | LEUKEMIA RESEARCH, Vol.33(7) : 1001-1004, 2009 | - |
dc.identifier.rimsid | 51697 | - |
dc.type.rims | ART | - |
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