Influence of replacement with Ringer's lactate for preoperative NPO deficits on blood glucose concentration in children undergoing strabismus surgery

Abstract

BACKGROUND: We investigated the effect that replacement with Ringer's lactate (RL) for preoperative NPO deficits might have on blood glucose concentration in children undergoing strabismus surgery. METHODS: Sixty children scheduled for strabismus surgery were enrolled in this study and RL was administered to all subjects for replacement of preoperative NPO deficits.Patients were randomly assigned to three groups according to the types of maintenance fluid employed during anesthesia.RL, 5% dextrose in one-fourth strength normal saline (D51/4NS), and an equal volume of D(5)1/4NS and RL each were used as maintenance fluids for Group 1, 2, and 3, respectively.After glycopyrrolate 0.004 mg/kg IV, anesthesia was induced with propofol 3 mg/kg and rocuronium 0.6 mg/kg.After tracheal intubation, anesthesia was maintained with 2-3 vol% sevoflurane in 50% air with oxygen.Blood glucose concentrations were checked from blood samples through a 22 gauge catheter inserted into a saphenous vein at the time of induction, 30 and 60 min after induction of anesthesia. RESULTS: There were no significant differences in baseline blood glucose levels at the time of induction of anesthesia among three groups.And the mean blood glucose concentrations remained unchanged throughout the study period in all groups.None of the patients were found to be hypoglycemic or hyperglycemic throughout the study period. CONCLUSIONS: This study shows that the replacement of preoperative NPO deficits with RL maintains the blood glucose concentration within physiological range throughout the operation and anesthetic recovery phase, regardless of the types of maintenance fluid.