Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin

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Authors: Mankil Jung ; Namsoo Park ; Hyung-In Moon ; Yongnam Lee ; Won-Yoon Chung ; Kwang-Kyun Park

Citation: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol.19(22) : 6303-6306, 2009

MeSH: Acetals/chemistry ; Amides/chemical synthesis ; Amides/chemistry* ; Animals ; Apoptosis/drug effects ; Apoptosis/physiology ; Artemisinins/chemical synthesis* ; Artemisinins/chemistry ; Cell Proliferation ; Drug Design ; Drug Screening Assays, Antitumor/methods ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/pathology ; Humans ; Inhibitory Concentration 50 ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Structure-Activity Relationship

Keywords: Anticancer activity ; Deoxoartemisinin ; Non-acetal type ; Antiangiogenesis

Abstract: Novel amide derivatives of C-12 non-acetal deoxoartemisinin were synthesized. Some of the derivatives had potent in vitro anticancer activity against major human cancer cell lines. The deoxoartemisinin amide trimer had potent in vivo antiangiogenic activity, according to the mouse matrigel plug assay

Full Text: http://www.sciencedirect.com/science/article/pii/S0960894X09013614

Appears in Collections:: 2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

Yonsei Authors: Park, Kwang Kyun(박광균)
Chung, Won Yoon(정원윤) https://orcid.org/0000-0001-8428-9005

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YUHSpace: Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin