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Multifunctional nanoparticles for combined doxorubicin and photothermal treatments

Authors
 Huiyul Park  ;  Jaemoon Yang  ;  Jaemin Lee  ;  Seungjoo Haam  ;  In-Hong Choi  ;  Kyung-Hwa Yoo 
Citation
 ACS NANO, Vol.3(10) : 2919-2926, 2009 
Journal Title
 ACS NANO 
ISSN
 1936-0851 
Issue Date
2009
MeSH
Antineoplastic Agents/chemistry* ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Biocompatible Materials/chemistry ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Doxorubicin/chemistry* ; Doxorubicin/metabolism ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Drug Carriers/chemistry* ; Gold/chemistry ; HeLa Cells ; Humans ; Hyperthermia, Induced* ; Infrared Rays/therapeutic use ; Lactic Acid/chemistry ; Metal Nanoparticles/chemistry* ; Microscopy, Fluorescence ; Nanomedicine/methods* ; Phototherapy* ; Polyglycolic Acid/chemistry
Keywords
chemo-photothermal treatment ; doxorubicin ; NIR resonance ; synergistic effect
Abstract
To facilitate combined doxorubicin and photothermal treatments, we developed doxorubicin-loaded poly(lactic-co-glycolic acid)-gold half-shell nanoparticles (DOX-loaded PLGA-Au H-S NPs) by depositing Au films on DOX-loaded PLGA NPs. As the PLGA NPs biodegraded, DOX was released, and heat was locally generated upon near-infrared (NIR) irradiation due to NIR resonance of DOX-loaded PLGA H-S NPs. Compared with chemotherapy or photothermal treatment alone, the combined treatment demonstrated a synergistic effect, resulting in higher therapeutic efficacy and shorter treatment times. Since our NPs selectively deliver both heat and drug to tumorigenic regions, they may improve the therapeutic effectiveness with minimal side effects.
Full Text
http://pubs.acs.org/doi/abs/10.1021/nn900215k
DOI
10.1021/nn900215k
Appears in Collections:
5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Choi, In Hong(최인홍) ORCID logo https://orcid.org/0000-0001-9851-0137
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105301
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