Synthesis and characterization of fluorescent magneto polymeric nanoparticles (FMPNs) for bimodal imaging probes

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Authors: Joseph Park ; Jaemoon Yang ; Jaemin Lee ; Eun-Kyung Lim ; Jin-Suck Suh ; Yong-Min Huh ; Seungjoo Haam

Citation: JOURNAL OF COLLOID AND INTERFACE SCIENCE, Vol.340(2) : 176-181, 2009

MeSH: Colloids/chemistry ; Diagnostic Imaging/methods* ; Ferrosoferric Oxide/chemical synthesis ; Ferrosoferric Oxide/chemistry* ; Fluorescent Dyes/chemistry* ; Hydrogen-Ion Concentration ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Magnetics ; Microscopy, Electron, Transmission ; Microscopy, Fluorescence ; Molecular Imaging/methods ; Nanoparticles/chemistry* ; Osmolar Concentration ; Oxazines/chemistry ; Particle Size ; Polymers/chemistry* ; Polymethyl Methacrylate/chemistry ; Polyvinyl Alcohol/chemistry ; Spectroscopy, Fourier Transform Infrared ; Surface Properties ; Thermogravimetry ; X-Ray Diffraction

Keywords: Magnetic resonance imaging ; Optical imaging ; Nile red ; Magnetic nanocrystal ; ATRP ; PMMA ; Dual imaging

Abstract: Novel bifunctional fluorescent magneto polymeric nanoprobes (FMPNs) were synthesized to provide simultaneous diagnostic information via magnetic resonance imaging (MRI) and optical imaging. FMPNs consist of ultra-sensitive magnetic nanocrystals that function as MR probes combined with Nile Red, which functions as a fluorescent probe. FMPNs were encapsulated by a nano-emulsion method in polyvinyl alcohol (PVA, 87-89% hydrolyzed) through a matrix of polymethyl methacrylate (PMMA). FMPNs exhibited excellent colloidal stability and monodispersity. The production of MR and optical images demonstrated that FMPNs have potential as dual-mode imaging agents

Full Text: http://www.sciencedirect.com/science/article/pii/S0021979709010522

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

Yonsei Authors: Suh, Jin Suck(서진석) https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) https://orcid.org/0000-0001-7365-0395
Huh, Yong Min(허용민) https://orcid.org/0000-0002-9831-4475

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