0 173

Cited 21 times in

Detrimental effect of postoperative complications on oncologic efficacy of R0 pancreatectomy in ductal adenocarcinoma of the pancreas

DC FieldValueLanguage
dc.contributor.author강창무-
dc.contributor.author김경식-
dc.contributor.author김동현-
dc.contributor.author이우정-
dc.contributor.author최기홍-
dc.contributor.author최진섭-
dc.date.accessioned2015-04-24T17:20:40Z-
dc.date.available2015-04-24T17:20:40Z-
dc.date.issued2009-
dc.identifier.issn1091-255X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/105222-
dc.description.abstractBACKGROUND: Margin-negative resection of pancreatic cancers has proven to be the most effective treatment to date. Although there are frequent surgery-related complications following pancreatectomy, the oncologic effect of these complications following pancreatectomy for pancreatic cancer has not been studied. MATERIALS AND METHODS: Retrospective observation of medical records of resected pancreatic ductal adenocarcinoma performed from January 1990 to June 2006 was used in this study. Potentially curative surgical resections of pancreatic ductal adenocarcinoma were performed on 103 patients. Survival was analyzed according to various clinicopathologic variables. RESULTS: Negative surgical margins (p = 0.0075) and absence of postoperative major complications related to surgery (p = 0.0116) were all significantly favorable prognostic factors in both univariate and multivariate analysis. Margin-negative pancreatectomy without major complications showed the most favorable oncologic outcomes in resected pancreatic cancer (median survival, 35.6 months; 95% confidential interval, 25.8-45.4 months), while major morbidities diminished survival benefit of R0 resection [R0-Cx(+), Exp(beta) = 1.925, p = 0.034, and R1, Exp(beta) = 3.129, p = 0.001]. CONCLUSION: Surgery-related major complication diminished the oncologic efficacy of R0 pancreatectomy. Margin-negative resection without major complication can enhance postoperative oncologic outcomes in ductal adenocarcinoma of the pancreas-
dc.description.statementOfResponsibilityopen-
dc.format.extent907~914-
dc.relation.isPartOfJOURNAL OF GASTROINTESTINAL SURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Pancreatic Ductal/mortality*-
dc.subject.MESHCarcinoma, Pancreatic Ductal/pathology-
dc.subject.MESHCarcinoma, Pancreatic Ductal/surgery*-
dc.subject.MESHCohort Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHNeoplasm, Residual-
dc.subject.MESHPancreatectomy/adverse effects*-
dc.subject.MESHPancreatic Neoplasms/mortality*-
dc.subject.MESHPancreatic Neoplasms/pathology-
dc.subject.MESHPancreatic Neoplasms/surgery*-
dc.subject.MESHPancreaticoduodenectomy/adverse effects*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTreatment Outcome-
dc.titleDetrimental effect of postoperative complications on oncologic efficacy of R0 pancreatectomy in ductal adenocarcinoma of the pancreas-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorChang Moo Kang-
dc.contributor.googleauthorDong Hyun Kim-
dc.contributor.googleauthorGi Hong Choi-
dc.contributor.googleauthorKyung Sik Kim-
dc.contributor.googleauthorJin Sub Choi-
dc.contributor.googleauthorWoo Jung Lee-
dc.identifier.doi10.1007/s11605-009-0823-9-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02993-
dc.contributor.localIdA00415-
dc.contributor.localIdA00088-
dc.contributor.localIdA00299-
dc.contributor.localIdA04046-
dc.contributor.localIdA04199-
dc.relation.journalcodeJ01418-
dc.identifier.eissn1873-4626-
dc.identifier.pmid19224295-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs11605-009-0823-9-
dc.subject.keywordPancreatic cancer-
dc.subject.keywordComplication-
dc.subject.keywordR0-
dc.subject.keywordPancreatectomy-
dc.subject.keywordSurvival-
dc.contributor.alternativeNameKang, Chang Moo-
dc.contributor.alternativeNameKim, Kyung Sik-
dc.contributor.alternativeNameKim, Dong Hyun-
dc.contributor.alternativeNameLee, Woo Jung-
dc.contributor.alternativeNameChoi, Gi Hong-
dc.contributor.alternativeNameChoi, Jin Sub-
dc.contributor.affiliatedAuthorLee, Woo Jung-
dc.contributor.affiliatedAuthorKim, Dong Hyun-
dc.contributor.affiliatedAuthorKang, Chang Moo-
dc.contributor.affiliatedAuthorKim, Kyung Sik-
dc.contributor.affiliatedAuthorChoi, Gi Hong-
dc.contributor.affiliatedAuthorChoi, Jin Sub-
dc.citation.volume13-
dc.citation.number5-
dc.citation.startPage907-
dc.citation.endPage914-
dc.identifier.bibliographicCitationJOURNAL OF GASTROINTESTINAL SURGERY, Vol.13(5) : 907-914, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.