Cited 26 times in
Detrimental effect of postoperative complications on oncologic efficacy of R0 pancreatectomy in ductal adenocarcinoma of the pancreas
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강창무 | - |
dc.contributor.author | 김경식 | - |
dc.contributor.author | 김동현 | - |
dc.contributor.author | 이우정 | - |
dc.contributor.author | 최기홍 | - |
dc.contributor.author | 최진섭 | - |
dc.date.accessioned | 2015-04-24T17:20:40Z | - |
dc.date.available | 2015-04-24T17:20:40Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1091-255X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105222 | - |
dc.description.abstract | BACKGROUND: Margin-negative resection of pancreatic cancers has proven to be the most effective treatment to date. Although there are frequent surgery-related complications following pancreatectomy, the oncologic effect of these complications following pancreatectomy for pancreatic cancer has not been studied. MATERIALS AND METHODS: Retrospective observation of medical records of resected pancreatic ductal adenocarcinoma performed from January 1990 to June 2006 was used in this study. Potentially curative surgical resections of pancreatic ductal adenocarcinoma were performed on 103 patients. Survival was analyzed according to various clinicopathologic variables. RESULTS: Negative surgical margins (p = 0.0075) and absence of postoperative major complications related to surgery (p = 0.0116) were all significantly favorable prognostic factors in both univariate and multivariate analysis. Margin-negative pancreatectomy without major complications showed the most favorable oncologic outcomes in resected pancreatic cancer (median survival, 35.6 months; 95% confidential interval, 25.8-45.4 months), while major morbidities diminished survival benefit of R0 resection [R0-Cx(+), Exp(beta) = 1.925, p = 0.034, and R1, Exp(beta) = 3.129, p = 0.001]. CONCLUSION: Surgery-related major complication diminished the oncologic efficacy of R0 pancreatectomy. Margin-negative resection without major complication can enhance postoperative oncologic outcomes in ductal adenocarcinoma of the pancreas | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 907~914 | - |
dc.relation.isPartOf | JOURNAL OF GASTROINTESTINAL SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma, Pancreatic Ductal/mortality* | - |
dc.subject.MESH | Carcinoma, Pancreatic Ductal/pathology | - |
dc.subject.MESH | Carcinoma, Pancreatic Ductal/surgery* | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Neoplasm, Residual | - |
dc.subject.MESH | Pancreatectomy/adverse effects* | - |
dc.subject.MESH | Pancreatic Neoplasms/mortality* | - |
dc.subject.MESH | Pancreatic Neoplasms/pathology | - |
dc.subject.MESH | Pancreatic Neoplasms/surgery* | - |
dc.subject.MESH | Pancreaticoduodenectomy/adverse effects* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Detrimental effect of postoperative complications on oncologic efficacy of R0 pancreatectomy in ductal adenocarcinoma of the pancreas | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Chang Moo Kang | - |
dc.contributor.googleauthor | Dong Hyun Kim | - |
dc.contributor.googleauthor | Gi Hong Choi | - |
dc.contributor.googleauthor | Kyung Sik Kim | - |
dc.contributor.googleauthor | Jin Sub Choi | - |
dc.contributor.googleauthor | Woo Jung Lee | - |
dc.identifier.doi | 10.1007/s11605-009-0823-9 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02993 | - |
dc.contributor.localId | A00415 | - |
dc.contributor.localId | A00088 | - |
dc.contributor.localId | A00299 | - |
dc.contributor.localId | A04046 | - |
dc.contributor.localId | A04199 | - |
dc.relation.journalcode | J01418 | - |
dc.identifier.eissn | 1873-4626 | - |
dc.identifier.pmid | 19224295 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs11605-009-0823-9 | - |
dc.subject.keyword | Pancreatic cancer | - |
dc.subject.keyword | Complication | - |
dc.subject.keyword | R0 | - |
dc.subject.keyword | Pancreatectomy | - |
dc.subject.keyword | Survival | - |
dc.contributor.alternativeName | Kang, Chang Moo | - |
dc.contributor.alternativeName | Kim, Kyung Sik | - |
dc.contributor.alternativeName | Kim, Dong Hyun | - |
dc.contributor.alternativeName | Lee, Woo Jung | - |
dc.contributor.alternativeName | Choi, Gi Hong | - |
dc.contributor.alternativeName | Choi, Jin Sub | - |
dc.contributor.affiliatedAuthor | Lee, Woo Jung | - |
dc.contributor.affiliatedAuthor | Kim, Dong Hyun | - |
dc.contributor.affiliatedAuthor | Kang, Chang Moo | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Sik | - |
dc.contributor.affiliatedAuthor | Choi, Gi Hong | - |
dc.contributor.affiliatedAuthor | Choi, Jin Sub | - |
dc.citation.volume | 13 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 907 | - |
dc.citation.endPage | 914 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GASTROINTESTINAL SURGERY, Vol.13(5) : 907-914, 2009 | - |
dc.identifier.rimsid | 53203 | - |
dc.type.rims | ART | - |
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