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Lymphoid tissue inducer cells: architects of CD4 immune responses in mice and men

DC Field Value Language
dc.contributor.author김경수-
dc.date.accessioned2015-04-24T17:15:24Z-
dc.date.available2015-04-24T17:15:24Z-
dc.date.issued2009-
dc.identifier.issn0009-9104-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/105051-
dc.description.abstractIn this review, we summarize the current understanding of the multiple functions of the mouse lymphoid tissue inducer (LTi) cells in: (i) the development of organized lymphoid tissue, (ii) the generation and maintenance of CD4-dependent immunity in adult lymphoid tissues; and (iii) the regulation of central tolerance in thymus. By contrast with mouse LTi cells, which have been well described, the human equivalent is only just beginning to be characterized. Human LTi-like cells expressing interleukin (IL)-22 have been identified recently and found to differentiate into natural killer (NK) cells. The relationship of LTi cells to NK cells is discussed in the light of several studies reporting a close relationship in the mouse between LTi cells and transcription factor retinoid-related orphan receptor gammat-dependent IL-22 producing NK cells in the gut. We also outline our data suggesting that these cells are present in adult human lymphoid tissues-
dc.description.statementOfResponsibilityopen-
dc.format.extent20~26-
dc.relation.isPartOfCLINICAL AND EXPERIMENTAL IMMUNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals CD4 Antigens/immunology* Humans Immunity, Innate Immunologic Memory Lymphoid Tissue/embryology* Lymphoid Tissue/immunology Mice Spleen/embryology Spleen/immunology T-Lymphocytes, Helper-Inducer/immunology* Thymus Gland/embryology Thymus Gland/immunology-
dc.titleLymphoid tissue inducer cells: architects of CD4 immune responses in mice and men-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학)-
dc.contributor.googleauthorM.-Y. Kim-
dc.contributor.googleauthorK.-S. Kim-
dc.contributor.googleauthorF. McConnell-
dc.contributor.googleauthorP. Lane-
dc.identifier.doi10.1111/j.1365-2249.2009.03932.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00298-
dc.relation.journalcodeJ00550-
dc.identifier.eissn1365-2249-
dc.identifier.pmid19659766-
dc.subject.keywordCD4 memory-
dc.subject.keywordLTi cells-
dc.subject.keywordlymphoid tissue-
dc.subject.keywordNK cells-
dc.contributor.alternativeNameKim, Kyung Su-
dc.contributor.affiliatedAuthorKim, Kyung Su-
dc.citation.volume157-
dc.citation.number1-
dc.citation.startPage20-
dc.citation.endPage26-
dc.identifier.bibliographicCitationCLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol.157(1) : 20-26, 2009-
dc.identifier.rimsid56256-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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