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Lymphoid tissue inducer cells: architects of CD4 immune responses in mice and men

Authors
 M.-Y. Kim  ;  K.-S. Kim  ;  F. McConnell  ;  P. Lane 
Citation
 CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol.157(1) : 20-26, 2009 
Journal Title
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
ISSN
 0009-9104 
Issue Date
2009
MeSH
Animals CD4 Antigens/immunology* Humans Immunity, Innate Immunologic Memory Lymphoid Tissue/embryology* Lymphoid Tissue/immunology Mice Spleen/embryology Spleen/immunology T-Lymphocytes, Helper-Inducer/immunology* Thymus Gland/embryology Thymus Gland/immunology
Keywords
CD4 memory ; LTi cells ; lymphoid tissue ; NK cells
Abstract
In this review, we summarize the current understanding of the multiple functions of the mouse lymphoid tissue inducer (LTi) cells in: (i) the development of organized lymphoid tissue, (ii) the generation and maintenance of CD4-dependent immunity in adult lymphoid tissues; and (iii) the regulation of central tolerance in thymus. By contrast with mouse LTi cells, which have been well described, the human equivalent is only just beginning to be characterized. Human LTi-like cells expressing interleukin (IL)-22 have been identified recently and found to differentiate into natural killer (NK) cells. The relationship of LTi cells to NK cells is discussed in the light of several studies reporting a close relationship in the mouse between LTi cells and transcription factor retinoid-related orphan receptor gammat-dependent IL-22 producing NK cells in the gut. We also outline our data suggesting that these cells are present in adult human lymphoid tissues
Files in This Item:
T200903462.pdf Download
DOI
10.1111/j.1365-2249.2009.03932.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Su(김경수) ORCID logo https://orcid.org/0000-0003-1460-0640
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105051
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