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The preoperative positivity for serum hepatitis B e antigen did not affect overall survival after curative resection of hepatitis B virus-related hepatocellular carcinoma

DC FieldValueLanguage
dc.contributor.author김동현-
dc.contributor.author김병로-
dc.contributor.author이우정-
dc.contributor.author전재윤-
dc.contributor.author최기홍-
dc.contributor.author최새별-
dc.contributor.author최진섭-
dc.contributor.author한광협-
dc.contributor.author강창무-
dc.contributor.author김경식-
dc.date.accessioned2015-04-24T17:13:41Z-
dc.date.available2015-04-24T17:13:41Z-
dc.date.issued2009-
dc.identifier.issn0815-9319-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104996-
dc.description.abstractBACKGROUND AND AIM: Previous studies have reported different risk factors for early and late intrahepatic recurrence after resection of hepatocellular carcinoma (HCC). However, the prognostic significance of the risk factors for early and late recurrence has not been clarified. METHODS: A total of 190 Hepatitis B surface antigen-positive patients who received curative resection for HCC were reviewed. We investigated prognostic factors for disease-free and overall survival after resection, and further analyzed the relationship between significant prognostic factors and risk factors for early (<or=14 months) and late (>14 months) intrahepatic recurrence. RESULTS: The 5-year disease-free and overall survival rates were 43.9% and 71.5%, respectively. In multivariate analysis, adverse prognostic factors for disease-free survival were presence of serum HBeAg, perioperative transfusion, and the presence of portal vein invasion (PVI) and/or intrahepatic metastasis (IM). Multivariate analysis revealed that overall survival was associated with ICG R15, serum albumin, Edmondson-Steiner grade, and the presence of PVI and/or IM. Independent risk factors for early intrahepatic recurrence were perioperative transfusion and PVI and/or IM, whereas positivity for HBeAg was the only risk factor for late recurrence. In addition, post-recurrence survival in patients with late intrahepatic recurrence was completely comparable to that of patients who never experienced recurrence. CONCLUSIONS: The presence of serum HBeAg, the risk factor for late intrahepatic recurrence did not affect overall survival after resection because late recurrence was relatively well controlled by current available treatments. To further improve long-term surgical outcomes, effective treatment and preventive methods for early intrahepatic recurrence should be investigated.-
dc.description.statementOfResponsibilityopen-
dc.format.extent391~398-
dc.relation.isPartOfJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHBlood Loss, Surgical/prevention & control-
dc.subject.MESHBlood Transfusion-
dc.subject.MESHCarcinoma, Hepatocellular/mortality-
dc.subject.MESHCarcinoma, Hepatocellular/surgery*-
dc.subject.MESHCarcinoma, Hepatocellular/virology-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHHepatectomy*-
dc.subject.MESHHepatitis B/complications*-
dc.subject.MESHHepatitis B/immunology-
dc.subject.MESHHepatitis B/mortality-
dc.subject.MESHHepatitis B/surgery-
dc.subject.MESHHepatitis B e Antigens/blood*-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHLiver Neoplasms/mortality-
dc.subject.MESHLiver Neoplasms/surgery*-
dc.subject.MESHLiver Neoplasms/virology-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHNeoplasm Recurrence, Local*-
dc.subject.MESHPortal Vein/pathology-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRisk Assessment-
dc.subject.MESHRisk Factors-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.titleThe preoperative positivity for serum hepatitis B e antigen did not affect overall survival after curative resection of hepatitis B virus-related hepatocellular carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorGi Hong Choi-
dc.contributor.googleauthorDong Hyun Kim-
dc.contributor.googleauthorSae Byeol Choi-
dc.contributor.googleauthorChang Moo Kang-
dc.contributor.googleauthorKyung Sik Kim-
dc.contributor.googleauthorJin Sub Choi-
dc.contributor.googleauthorWoo Jung Lee-
dc.contributor.googleauthorKwang Hyub Han-
dc.contributor.googleauthorChae Yoon Chon-
dc.contributor.googleauthorByong Ro Kim-
dc.identifier.doi10.1111/j.1440-1746.2008.05637.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00496-
dc.contributor.localIdA04046-
dc.contributor.localIdA04069-
dc.contributor.localIdA04199-
dc.contributor.localIdA04268-
dc.contributor.localIdA00088-
dc.contributor.localIdA00299-
dc.contributor.localIdA02993-
dc.contributor.localIdA03544-
dc.contributor.localIdA00415-
dc.relation.journalcodeJ01417-
dc.identifier.eissn1440-1746-
dc.identifier.pmid19032452-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2008.05637.x/abstract-
dc.subject.keywordcurative resection-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordprognostic factors-
dc.subject.keywordrisk factors for intrahepatic recurrence-
dc.contributor.alternativeNameKim, Dong Hyun-
dc.contributor.alternativeNameKim, Byong Ro-
dc.contributor.alternativeNameLee, Woo Jung-
dc.contributor.alternativeNameChon, Chae Yoon-
dc.contributor.alternativeNameChoi, Gi Hong-
dc.contributor.alternativeNameChoi, Sae Byeol-
dc.contributor.alternativeNameChoi, Jin Sub-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.alternativeNameKang, Chang Moo-
dc.contributor.alternativeNameKim, Kyung Sik-
dc.contributor.affiliatedAuthorKim, Byong Ro-
dc.contributor.affiliatedAuthorChoi, Gi Hong-
dc.contributor.affiliatedAuthorChoi, Sae Byeol-
dc.contributor.affiliatedAuthorChoi, Jin Sub-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKang, Chang Moo-
dc.contributor.affiliatedAuthorKim, Kyung Sik-
dc.contributor.affiliatedAuthorLee, Woo Jung-
dc.contributor.affiliatedAuthorChon, Chae Yoon-
dc.contributor.affiliatedAuthorKim, Dong Hyun-
dc.citation.volume24-
dc.citation.number3-
dc.citation.startPage391-
dc.citation.endPage398-
dc.identifier.bibliographicCitationJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.24(3) : 391-398, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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