Cited 25 times in
Multiplication of neutrophil and monocyte counts (MNM) as an easily obtainable tumour marker for cervical cancer.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김재훈 | - |
dc.contributor.author | 조한별 | - |
dc.date.accessioned | 2015-04-24T17:12:26Z | - |
dc.date.available | 2015-04-24T17:12:26Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1752-0363 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104956 | - |
dc.description.abstract | Simple, non-aversive methods to identify cervical neoplasia are needed. The purpose of this study was to investigate the clinical value of differential white blood cell (WBC) counts as a biomarker for cervical neoplasia. We performed a retrospective review of laboratory results in 407 cervical cancers, 495 cervical intraepithelial neoplasias (CIN) and 916 healthy controls. Because pretreatment neutrophil and monocyte counts showed the potential as a biomarker, we combined these parameters and designated this combined marker MNM (multiplication of neutrophil and monocyte counts). MNM showed a sensitivity of 53.1% and a specificity of 78.1%, which are much higher than those of SCC-Ag. On Cox multivariate analysis, MNM positivity (hazard ratio = 2.82, p = 0.042), stage and tumour size were independent predictors of poor prognosis. Our findings suggest that pretreatment MNM could be a candidate as a simple and cost-effective biomarker in cervical cancer | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 161~170 | - |
dc.relation.isPartOf | BIOMARKERS IN MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Biomarkers, Tumor/blood* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Leukocyte Count* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Monocytes/cytology* | - |
dc.subject.MESH | Neutrophils/cytology* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Uterine Cervical Neoplasms/blood | - |
dc.subject.MESH | Uterine Cervical Neoplasms/diagnosis* | - |
dc.title | Multiplication of neutrophil and monocyte counts (MNM) as an easily obtainable tumour marker for cervical cancer. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Hanbyoul Cho | - |
dc.contributor.googleauthor | Jae-Hoon Kim | - |
dc.identifier.doi | 10.1080/13547500902777616 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00876 | - |
dc.contributor.localId | A03921 | - |
dc.relation.journalcode | J03118 | - |
dc.identifier.eissn | 1752-0371 | - |
dc.identifier.pmid | 19399661 | - |
dc.identifier.url | http://informahealthcare.com/doi/abs/10.1080/13547500902777616 | - |
dc.subject.keyword | White blood cell | - |
dc.subject.keyword | neutrophil, monocyte | - |
dc.subject.keyword | cervical cancer | - |
dc.subject.keyword | tumour marker | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.alternativeName | Cho, Han Byoul | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Cho, Han Byoul | - |
dc.citation.volume | 14 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 161 | - |
dc.citation.endPage | 170 | - |
dc.identifier.bibliographicCitation | BIOMARKERS IN MEDICINE, Vol.14(3) : 161-170, 2009 | - |
dc.identifier.rimsid | 55102 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.