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Multiplication of neutrophil and monocyte counts (MNM) as an easily obtainable tumour marker for cervical cancer.

Authors
 Hanbyoul Cho  ;  Jae-Hoon Kim 
Citation
 BIOMARKERS IN MEDICINE, Vol.14(3) : 161-170, 2009 
Journal Title
 BIOMARKERS IN MEDICINE 
ISSN
 1752-0363 
Issue Date
2009
MeSH
Adult ; Biomarkers, Tumor/blood* ; Case-Control Studies ; Female ; Humans ; Leukocyte Count* ; Middle Aged ; Monocytes/cytology* ; Neutrophils/cytology* ; Prognosis ; Retrospective Studies ; Uterine Cervical Neoplasms/blood ; Uterine Cervical Neoplasms/diagnosis*
Keywords
White blood cell ; neutrophil, monocyte ; cervical cancer ; tumour marker
Abstract
Simple, non-aversive methods to identify cervical neoplasia are needed. The purpose of this study was to investigate the clinical value of differential white blood cell (WBC) counts as a biomarker for cervical neoplasia. We performed a retrospective review of laboratory results in 407 cervical cancers, 495 cervical intraepithelial neoplasias (CIN) and 916 healthy controls. Because pretreatment neutrophil and monocyte counts showed the potential as a biomarker, we combined these parameters and designated this combined marker MNM (multiplication of neutrophil and monocyte counts). MNM showed a sensitivity of 53.1% and a specificity of 78.1%, which are much higher than those of SCC-Ag. On Cox multivariate analysis, MNM positivity (hazard ratio = 2.82, p = 0.042), stage and tumour size were independent predictors of poor prognosis. Our findings suggest that pretreatment MNM could be a candidate as a simple and cost-effective biomarker in cervical cancer
Full Text
http://informahealthcare.com/doi/abs/10.1080/13547500902777616
DOI
10.1080/13547500902777616
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Hoon(김재훈) ORCID logo https://orcid.org/0000-0001-6599-7065
Cho, Hanbyoul(조한별) ORCID logo https://orcid.org/0000-0002-6177-1648
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104956
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