Cited 13 times in
Efficacy of ER-alpha polymorphisms and the intrafollicular IGF system for predicting pregnancy in IVF-ET patients.
DC Field | Value | Language |
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dc.contributor.author | 최영식 | - |
dc.date.accessioned | 2015-04-24T17:11:42Z | - |
dc.date.available | 2015-04-24T17:11:42Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0378-7346 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104934 | - |
dc.description.abstract | AIMS: To evaluate the efficacies of the estrogen receptor-alpha (ER-alpha) gene polymorphisms and of the intrafollicular insulin-like growth factor (IGF) system for predicting pregnancy in in vitro fertilization and embryo transfer (IVF-ET) patients. METHODS: A total of 96 patients undergoing IVF-ET were included in this study. Genotyping for the ER-alpha gene PvuII and XbaI polymorphisms was performed using polymerase-chain reaction and single base extension method. Follicular fluid (FF) IGF-I, IGF-II, and IGFBP-3 concentrations were measured by RIA, and IGFBP-4 by ELISA. We compared, between pregnant (n = 28) and non-pregnant groups (n = 68), the allele frequency, genotype distribution and haplotype distribution of PvuII and XbaI polymorphisms, and then FF IGF-I, IGF-II, IGFBP-3, IGFBP-4 concentrations and their ratios. RESULTS: No significant differences were found between the two groups in terms of allele, genotype or haplotype distributions of the ER-alpha gene PvuII and XbaI polymorphisms between the two groups. The mean FF IGF-I/IGFBP-3 ratio was significantly higher in the pregnant group (5.9 +/- 1.5 vs. 4.8 +/- 1.5 x 10(-2)). CONCLUSIONS: The intrafollicular IGF-I/IGFBP-3 ratio of the FF of the dominant follicle during oocyte retrieval appears to be related to the establishment of pregnancy in IVF-ET patients, whereas the ER-alpha gene PvuII and XbaI polymorphisms do not. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 73~80 | - |
dc.relation.isPartOf | GYNECOLOGIC AND OBSTETRIC INVESTIGATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Biomarkers/analysis | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Embryo Transfer | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Estrogen Receptor alpha/genetics | - |
dc.subject.MESH | Estrogen Receptor alpha/metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fertilization in Vitro | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin-Like Growth Factor Binding Protein 3/genetics | - |
dc.subject.MESH | Insulin-Like Growth Factor Binding Protein 3/metabolism | - |
dc.subject.MESH | Insulin-Like Growth Factor Binding Protein 4/analysis | - |
dc.subject.MESH | Insulin-Like Growth Factor Binding Protein 4/genetics | - |
dc.subject.MESH | Insulin-Like Growth Factor Binding Protein 4/metabolism | - |
dc.subject.MESH | Insulin-Like Growth Factor Binding Proteins/genetics | - |
dc.subject.MESH | Insulin-Like Growth Factor Binding Proteins/metabolism* | - |
dc.subject.MESH | Insulin-Like Growth Factor I/genetics | - |
dc.subject.MESH | Insulin-Like Growth Factor I/metabolism | - |
dc.subject.MESH | Insulin-Like Growth Factor II/genetics | - |
dc.subject.MESH | Insulin-Like Growth Factor II/metabolism | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Polymorphism, Genetic* | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Pregnancy | - |
dc.subject.MESH | Pregnancy Outcome* | - |
dc.subject.MESH | Probability | - |
dc.subject.MESH | Radioimmunoassay | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Somatomedins/analysis | - |
dc.subject.MESH | Somatomedins/metabolism* | - |
dc.title | Efficacy of ER-alpha polymorphisms and the intrafollicular IGF system for predicting pregnancy in IVF-ET patients. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Young Sik Choi | - |
dc.contributor.googleauthor | Seok Hyun Kim | - |
dc.contributor.googleauthor | Seung-Yup Ku | - |
dc.contributor.googleauthor | Byung Chul Jee | - |
dc.contributor.googleauthor | Chang Suk Suh | - |
dc.contributor.googleauthor | Young Min Choi | - |
dc.contributor.googleauthor | Jung Gu Kim | - |
dc.contributor.googleauthor | Shin Yong Moon | - |
dc.identifier.doi | 10.1159/000162104 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04114 | - |
dc.relation.journalcode | J00955 | - |
dc.identifier.eissn | 1423-002X | - |
dc.identifier.pmid | 18843190 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/162104 | - |
dc.subject.keyword | Estrogen receptor-α | - |
dc.subject.keyword | Polymorphism | - |
dc.subject.keyword | Insulin-like growth factor | - |
dc.subject.keyword | Insulin-like growth factor binding protein | - |
dc.subject.keyword | In vitro fertilization and embryo transfer | - |
dc.contributor.alternativeName | Choi, Young Sik | - |
dc.contributor.affiliatedAuthor | Choi, Young Sik | - |
dc.citation.volume | 67 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 73 | - |
dc.citation.endPage | 80 | - |
dc.identifier.bibliographicCitation | GYNECOLOGIC AND OBSTETRIC INVESTIGATION, Vol.67(2) : 73-80, 2009 | - |
dc.identifier.rimsid | 54675 | - |
dc.type.rims | ART | - |
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