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Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis

DC FieldValueLanguage
dc.contributor.author손명현-
dc.date.accessioned2015-04-24T17:10:59Z-
dc.date.available2015-04-24T17:10:59Z-
dc.date.issued2009-
dc.identifier.issn0022-1007-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104912-
dc.description.abstractMouse breast regression protein 39 (BRP-39; Chi3l1) and its human homologue YKL-40 are chitinase-like proteins that lack chitinase activity. Although YKL-40 is expressed in exaggerated quantities and correlates with disease activity in asthma and many other disorders, the biological properties of BRP-39/YKL-40 have only been rudimentarily defined. We describe the generation and characterization of BRP-39(-/-) mice, YKL-40 transgenic mice, and mice that lack BRP-39 and produce YKL-40 only in their pulmonary epithelium. Studies of these mice demonstrated that BRP-39(-/-) animals have markedly diminished antigen-induced Th2 responses and that epithelial YKL-40 rescues the Th2 responses in these animals. The ability of interleukin13 to induce tissue inflammation and fibrosis was also markedly diminished in the absence of BRP-39. Mechanistic investigations demonstrated that BRP-39 and YKL-40 play an essential role in antigen sensitization and immunoglobulin E induction, stimulate dendritic cell accumulation and activation, and induce alternative macrophage activation. These proteins also inhibit inflammatory cell apoptosis/cell death while inhibiting Fas expression, activating protein kinase B/AKT, and inducing Faim 3. These studies establish novel regulatory roles for BRP-39/YKL-40 in the initiation and effector phases of Th2 inflammation and remodeling and suggest that these proteins are therapeutic targets in Th2- and macrophage-mediated disorders-
dc.description.statementOfResponsibilityopen-
dc.format.extent1149~1166-
dc.relation.isPartOfJOURNAL OF EXPERIMENTAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdipokines-
dc.subject.MESHAnimals-
dc.subject.MESHApoptosis/genetics-
dc.subject.MESHApoptosis/physiology*-
dc.subject.MESHAsthma/genetics-
dc.subject.MESHChitinase-3-Like Protein 1-
dc.subject.MESHConserved Sequence-
dc.subject.MESHCoronary Disease/genetics-
dc.subject.MESHGlycoproteins/deficiency-
dc.subject.MESHGlycoproteins/genetics*-
dc.subject.MESHGlycoproteins/therapeutic use-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin E/immunology-
dc.subject.MESHInflammation/chemically induced-
dc.subject.MESHInflammation/genetics*-
dc.subject.MESHInflammation/pathology-
dc.subject.MESHInterleukin-13/genetics*-
dc.subject.MESHLectins-
dc.subject.MESHMice-
dc.subject.MESHMice, Knockout-
dc.subject.MESHMice, Transgenic-
dc.subject.MESHOvalbumin-
dc.titleRole of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorChun Geun Lee-
dc.contributor.googleauthorDominik Hartl-
dc.contributor.googleauthorGap Ryol Lee-
dc.contributor.googleauthorBarbara Koller-
dc.contributor.googleauthorHiroshi Matsuura-
dc.contributor.googleauthorCarla A. Da Silva-
dc.contributor.googleauthorMyung Hyun Sohn-
dc.contributor.googleauthorLauren Cohn-
dc.contributor.googleauthorRobert J. Homer-
dc.contributor.googleauthorAlexander A. Kozhich-
dc.contributor.googleauthorAlison Humbles-
dc.contributor.googleauthorJennifer Kearley-
dc.contributor.googleauthorAnthony Coyle-
dc.contributor.googleauthorGeoffrey Chupp-
dc.contributor.googleauthorJennifer Reed-
dc.contributor.googleauthorRichard A. Flavell-
dc.contributor.googleauthorJack A. Elias-
dc.identifier.doi10.1084/jem.20081271-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01967-
dc.relation.journalcodeJ01409-
dc.identifier.eissn1540-9538-
dc.identifier.pmid19414556-
dc.contributor.alternativeNameSon, Myung Hyun-
dc.contributor.affiliatedAuthorSon, Myung Hyun-
dc.citation.volume206-
dc.citation.number5-
dc.citation.startPage1149-
dc.citation.endPage1166-
dc.identifier.bibliographicCitationJOURNAL OF EXPERIMENTAL MEDICINE, Vol.206(5) : 1149-1166, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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