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Assessment of subclinical coronary atherosclerosis in asymptomatic patients with type 2 diabetes mellitus with single photon emission computed tomography and coronary computed tomography angiography

DC Field Value Language
dc.contributor.author장혁재-
dc.date.accessioned2015-04-24T17:10:05Z-
dc.date.available2015-04-24T17:10:05Z-
dc.date.issued2009-
dc.identifier.issn0002-9149-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104885-
dc.description.abstractWe evaluated the characteristics of coronary artery disease in asymptomatic patients with type 2 diabetes mellitus (DM) using single photon emission computed tomography (SPECT) and coronary computed tomographic angiography (CCTA). A total of 116 patients with DM without abnormal electrocardiographic findings or evidence of peripheral arterial disease (number of risk factors > or =2; 62 +/- 7 years, 59% men) underwent CCTA and SPECT. Of the 116 patients with DM, 88 (76%) had a normal single photon emission computed tomographic findings, and 28 (24%) had abnormal perfusion defects. Of the 116 patients, 92 (79%) had atherosclerotic plaques (2 +/- 2 segments per subject), and 20 (17%) had significant stenosis seen on CCTA. Patients with DM and normal findings on SPECT had a similar prevalence of atherosclerotic plaque (78% vs 82%), significant stenosis (15% vs 25%), severe stenosis (7% vs 7%), and calcified (40% vs 43%), mixed (49% vs 57%), and noncalcified plaques (26% vs 29%) and a high (>100) coronary artery calcium score (32% vs 29%; all p >0.05) compared to those with abnormal findings on SPECT. During the mid-term follow-up (24 +/- 4 months), 5 cardiac events occurred in patients with DM and normal findings on SPECT, only in those with occult CAD on CCTA: 1 sudden cardiac death and 4 revascularization procedures. In conclusion, a significant percentage of patients with DM and normal eletrocardiographic findings, no peripheral arterial disease, and normal findings on SPECT have evidence of occult CAD on CCTA. Furthermore, a small percentage had had a cardiac event by mid-term follow-up. SPECT showed limited capability to differentiate the coronary risks between patients with DM and no coronary plaque and from those with a certain degree of disease; 2 circumstances that represent different coronary risks-
dc.description.statementOfResponsibilityopen-
dc.format.extent890~896-
dc.relation.isPartOfAMERICAN JOURNAL OF CARDIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAge Distribution-
dc.subject.MESHAged-
dc.subject.MESHCohort Studies-
dc.subject.MESHCoronary Angiography/methods*-
dc.subject.MESHCoronary Artery Disease/diagnostic imaging*-
dc.subject.MESHCoronary Artery Disease/epidemiology-
dc.subject.MESHDiabetes Mellitus, Type 2/diagnosis*-
dc.subject.MESHDiabetes Mellitus, Type 2/epidemiology-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProbability-
dc.subject.MESHProspective Studies-
dc.subject.MESHReference Values-
dc.subject.MESHRisk Assessment-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHSex Distribution-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTomography, Emission-Computed, Single-Photon/methods*-
dc.subject.MESHTomography, X-Ray Computed/methods*-
dc.titleAssessment of subclinical coronary atherosclerosis in asymptomatic patients with type 2 diabetes mellitus with single photon emission computed tomography and coronary computed tomography angiography-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorEue-Keun Choi-
dc.contributor.googleauthorEun Ju Chun-
dc.contributor.googleauthorSang-Il Choi-
dc.contributor.googleauthorSung-A Chang-
dc.contributor.googleauthorSung-Hee Choi-
dc.contributor.googleauthorSoo Lim-
dc.contributor.googleauthorJuan J. Rivera-
dc.contributor.googleauthorKhurram Nasir-
dc.contributor.googleauthorRoger S. Blumenthal-
dc.contributor.googleauthorHak-Chul Jang-
dc.contributor.googleauthorHyuk-Jae Chang-
dc.identifier.doi10.1016/j.amjcard.2009.05.026-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03490-
dc.relation.journalcodeJ00071-
dc.identifier.eissn1879-1913-
dc.identifier.pmid19766752-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0002914909010935-
dc.contributor.alternativeNameChang, Hyuck Jae-
dc.contributor.affiliatedAuthorChang, Hyuck Jae-
dc.citation.volume104-
dc.citation.number7-
dc.citation.startPage890-
dc.citation.endPage896-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF CARDIOLOGY, Vol.104(7) : 890-896, 2009-
dc.identifier.rimsid42548-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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