Cited 2 times in
Standardized genetic alteration score and predicted score for predicting recurrence status of gastric cancer
DC Field | Value | Language |
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dc.contributor.author | 정현철 | - |
dc.date.accessioned | 2015-04-24T17:09:15Z | - |
dc.date.available | 2015-04-24T17:09:15Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0171-5216 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104860 | - |
dc.description.abstract | PURPOSE: To build a standardized genetic alteration score (SGAS) based on genes that are related to a patient's recurrence status, and to obtain the predicted score (PS) for predicting a patient's recurrence status, which reflects the genetic information of the gastric cancer patient. METHODS: SGAS was constructed using linear combinations that best account for the variability in the data. This methodology was fit to and validated using cDNA microarray-based CGH data obtained from the Cancer Metastasis Research Center at Yonsei University. RESULTS: When classifying cancer patients, the accuracy was 92.59% in the leave-one-out validation method. CONCLUSIONS: SGAS provided PS for the risk of recurrence, which was capable of discriminating a patient's recurrence status. A total of 59 genes were found to have a high frequency of alteration in either the recurrence or non-recurrence status. SGAS was found to be a significant risk factor on recurrence and explained 31% variability of the 59 genes. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1501~1512 | - |
dc.relation.isPartOf | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Dosage* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Recurrence, Local/epidemiology* | - |
dc.subject.MESH | Probability | - |
dc.subject.MESH | Stomach Neoplasms/genetics* | - |
dc.title | Standardized genetic alteration score and predicted score for predicting recurrence status of gastric cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Mijung Kim | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.identifier.doi | 10.1007/s00432-009-0597-1 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03773 | - |
dc.relation.journalcode | J01283 | - |
dc.identifier.eissn | 1432-1335 | - |
dc.identifier.pmid | 19449028 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00432-009-0597-1 | - |
dc.subject.keyword | cDNA microarray-based CGH | - |
dc.subject.keyword | Gene copy number change | - |
dc.subject.keyword | Correct classification rate | - |
dc.subject.keyword | Factor analysis | - |
dc.subject.keyword | Logistic regression model | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.citation.volume | 135 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1501 | - |
dc.citation.endPage | 1512 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, Vol.135(11) : 1501-1512, 2009 | - |
dc.identifier.rimsid | 42528 | - |
dc.type.rims | ART | - |
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