Cited 4 times in
Classical PKC is not associated with defective insulin signaling in patients with impaired glucose tolerance.
DC Field | Value | Language |
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dc.contributor.author | 이현철 | - |
dc.date.accessioned | 2015-04-24T17:07:13Z | - |
dc.date.available | 2015-04-24T17:07:13Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104798 | - |
dc.description.abstract | BACKGROUND AND AIM: To investigate the role of insulin signaling defects in impaired glucose tolerance (IGT), we assessed the functionality of the insulin signaling cascade before and after insulin stimulation in both IGT group and control group. METHODS: Ten IGT subjects and 15 control subjects were recruited for this study. Whole-body insulin-mediated glucose uptake was determined using a euglycemic hyperinsulinemic clamp test. Muscle biopsies were obtained from the vastus lateralis muscle before and after insulin stimulation, to assess the insulin signaling cascade. RESULTS: The insulin-stimulated incremental changes in phosphorylated IR-beta, IRS, Akt, and GSK-3 beta and in the membrane-associated PKC-zeta protein level were reduced in the IGT group compared with those in the control group (p<0.05). The membrane-associated PKC-lambda protein level was also reduced in the IGT group, but not significantly so (p=0.08). The incremental changes in the protein levels of PKC-alpha, -beta, and -theta were not significantly different between the two groups. CONCLUSION: The subjects with IGT showed decreased membrane-associated PKC-zeta/lambda activity in response to insulin stimulation, as well as defects in early insulin signaling. Our results suggest that membrane-associated PKC-alpha and -beta may not be associated with insulin resistance in IGT. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 334~340 | - |
dc.relation.isPartOf | DIABETES RESEARCH AND CLINICAL PRACTICE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Biopsy | - |
dc.subject.MESH | Blood Glucose/analysis | - |
dc.subject.MESH | Cholesterol, HDL/blood | - |
dc.subject.MESH | Cholesterol, LDL/blood | - |
dc.subject.MESH | Glucose Clamp Technique | - |
dc.subject.MESH | Glucose Intolerance/enzymology* | - |
dc.subject.MESH | Glucose Intolerance/physiopathology | - |
dc.subject.MESH | Glucose Tolerance Test | - |
dc.subject.MESH | Glycogen Synthase Kinase 3/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyperinsulinism | - |
dc.subject.MESH | Insulin/blood | - |
dc.subject.MESH | Insulin/physiology* | - |
dc.subject.MESH | Insulin Resistance/physiology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Muscle, Skeletal/cytology | - |
dc.subject.MESH | Muscle, Skeletal/enzymology | - |
dc.subject.MESH | Muscle, Skeletal/pathology | - |
dc.subject.MESH | Protein Kinase C/blood* | - |
dc.subject.MESH | Reference Values | - |
dc.subject.MESH | Signal Transduction | - |
dc.title | Classical PKC is not associated with defective insulin signaling in patients with impaired glucose tolerance. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Do Min Kim | - |
dc.contributor.googleauthor | Hyun Ju Jang | - |
dc.contributor.googleauthor | Seung Jin Han | - |
dc.contributor.googleauthor | Eun Suk Ha | - |
dc.contributor.googleauthor | Yun Kyung Kim | - |
dc.contributor.googleauthor | Jee Won Park | - |
dc.contributor.googleauthor | Kyoung Eun Song | - |
dc.contributor.googleauthor | Sun Hye Jung | - |
dc.contributor.googleauthor | Sang Mi Ahn | - |
dc.contributor.googleauthor | Sung E. Choi | - |
dc.contributor.googleauthor | Hae Jin Kim | - |
dc.contributor.googleauthor | Dae Jung Kim | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.contributor.googleauthor | Kwan Woo Lee | - |
dc.identifier.doi | 10.1016/j.diabres.2008.11.035 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03301 | - |
dc.relation.journalcode | J00723 | - |
dc.identifier.eissn | 1872-8227 | - |
dc.identifier.pmid | 19124171 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0168822708005962 | - |
dc.subject.keyword | Insulin resistance | - |
dc.subject.keyword | Impaired glucose tolerance (IGT) | - |
dc.subject.keyword | Insulin signaling | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.citation.volume | 83 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 334 | - |
dc.citation.endPage | 340 | - |
dc.identifier.bibliographicCitation | DIABETES RESEARCH AND CLINICAL PRACTICE, Vol.83(3) : 334-340, 2009 | - |
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