411 679

Cited 19 times in

The impact of dialysis modality on skin hyperpigmentation in haemodialysis patients

DC Field Value Language
dc.contributor.author문성진-
dc.contributor.author이정은-
dc.contributor.author유태현-
dc.contributor.author강신욱-
dc.date.accessioned2015-04-24T17:03:06Z-
dc.date.available2015-04-24T17:03:06Z-
dc.date.issued2009-
dc.identifier.issn0931-0509-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104667-
dc.description.abstractBACKGROUND: Skin hyperpigmentation in end-stage renal disease (ESRD) patients has been attributed to the accumulation of middle-molecular-weight (MMW) substances. Although an MMW mechanism suggests that hyperpigmentation may be improved by high-flux haemodialysis (HF-HD) and haemodiafiltration (HDF), this possibility has not been explored. In the present study, we investigated the impact of different dialysis modalities on skin colour in HD patients. METHODS: Eighty-two ESRD patients on HD were divided into low-flux HD (LF-HD), HF-HD and HDF groups. The melanin index (MI) and erythema index (EI) of the abdomen and the flexor side of the forearm (non-sun-exposed areas) and the forehead (sun-exposed area) were determined by using a narrow-band reflectance spectrophotometer at baseline and after 12 months. RESULTS: Even though absolute values of baseline and follow-up MI and EI of the three sites were comparable among the three groups, forehead MI and EI were significantly decreased after 12 months in the HDF group (P < 0.05). In addition, the change in forehead MI was significantly greater in the HDF than in the LF-HD group (-1.0 +/- 2.4% versus 0.3 +/- 1.6%, P < 0.05). Moreover, beta(2)-microglobulin reduction rates were negatively correlated with both changes in forehead MI (P < 0.01) and EI (P < 0.05). CONCLUSIONS: Skin colour of sun-exposed areas was signi- ficantly decreased in ESRD patients receiving HDF therapy, suggesting that enhanced removal of MMW substances by convection may prevent or reduce hyperpigmentation in HD patients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent2803~2809-
dc.relation.isPartOfNEPHROLOGY DIALYSIS TRANSPLANTATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHErythema/etiology-
dc.subject.MESHFemale-
dc.subject.MESHHemodiafiltration-
dc.subject.MESHHumans-
dc.subject.MESHKidney Failure, Chronic/complications-
dc.subject.MESHKidney Failure, Chronic/metabolism-
dc.subject.MESHKidney Failure, Chronic/pathology-
dc.subject.MESHKidney Failure, Chronic/therapy-
dc.subject.MESHMale-
dc.subject.MESHMelanins/metabolism-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPigmentation Disorders/etiology-
dc.subject.MESHPigmentation Disorders/metabolism-
dc.subject.MESHPigmentation Disorders/pathology-
dc.subject.MESHRenal Dialysis/methods*-
dc.subject.MESHSkin Pigmentation*-
dc.subject.MESHSunlight/adverse effects-
dc.subject.MESHToxins, Biological/metabolism-
dc.subject.MESHbeta 2-Microglobulin/metabolism-
dc.titleThe impact of dialysis modality on skin hyperpigmentation in haemodialysis patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSung Jin Moon-
dc.contributor.googleauthorDong Ki Kim-
dc.contributor.googleauthorJae Hyun Chang-
dc.contributor.googleauthorChan Ho Kim-
dc.contributor.googleauthorHyun Wook Kim-
dc.contributor.googleauthorSun Young Park-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorJung Eun Lee-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorDae Suk Han-
dc.contributor.googleauthorShin-Wook Kang-
dc.identifier.doi10.1093/ndt/gfp143-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01364-
dc.contributor.localIdA02526-
dc.contributor.localIdA00053-
dc.contributor.localIdA03119-
dc.relation.journalcodeJ02316-
dc.identifier.eissn1460-2385-
dc.identifier.pmid19342419-
dc.subject.keyword[beta]2-microglobulin-
dc.subject.keywordhaemodiafiltration-
dc.subject.keywordhyperpigmentation-
dc.subject.keywordlow-flux haemodialysis-
dc.subject.keywordspectrophotometer-
dc.contributor.alternativeNameMoon, Sung Jin-
dc.contributor.alternativeNameLee, Jung Eun-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.affiliatedAuthorMoon, Sung Jin-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorLee, Jung Eun-
dc.citation.volume24-
dc.citation.number9-
dc.citation.startPage2803-
dc.citation.endPage2809-
dc.identifier.bibliographicCitationNEPHROLOGY DIALYSIS TRANSPLANTATION, Vol.24(9) : 2803-2809, 2009-
dc.identifier.rimsid52846-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.