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비소세포성 폐암으로 수술 후 방사선치료가 시행된 N2병기 환자들에서 다발 부위 종격동 림프절 전이 여부에 따른 N2병기 구분의 임상적 의미

DC FieldValueLanguage
dc.contributor.author김주항-
dc.contributor.author이익재-
dc.contributor.author이진구-
dc.contributor.author이창걸-
dc.contributor.author정경영-
dc.contributor.author조병철-
dc.contributor.author김용배-
dc.date.accessioned2015-04-24T17:02:40Z-
dc.date.available2015-04-24T17:02:40Z-
dc.date.issued2009-
dc.identifier.issn1229-8719-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104653-
dc.description.abstractPurpose: We wanted to evaluate the prognostic factors for the pathologic N2 non-small cell lung cancer (NSCLC) patients who were treated by postoperative radiotherapy. Materials and Methods: We retrospectively reviewed 112 pN2 NSCLC patients who underwent surgery and postoperative radiotherapy (PORT) From January 1999 to February 2008. Seventy-five (67%) patients received segmentectomy or lobectomy and 37 (33%) patients received pneumonectomy. the resection margin was negative in 94 patients, and it was positive or close in 18 patients. Chemotherapy was administered to 103 (92%) patients. Nine (8%) patients received PORT alone. the median radiation dose was 54 Gy (range, 45 to 66), and the fraction size was 1.8~2 Gy. Results: the 2-year overall survival (OS) rate was 60.2% and the disease free survival (DFS) rate was 44.7% for all the patients. Univariate analysis showed that the patients with multiple-station N2 disease had significantly reduced OS and DFS (p=0.047, p=0.007) and the patients with an advanced T stage (≥T3) had significantly reduced OS and DFS (p<0.001, p=0.025). A large tumor size (≥5 cm) and positive lymphovascular invasion reduced the OS (p=0.035, 0.034). Using multivariate analysis, we found that multiple-station N2 disease and an advanced T stage (≥T3) significantly reduced the OS and DFS. Seventy one patients (63.4%) had recurrence of disease. the patterns of failure were loco-regional in 23 (20.5%) patients, distant failure in 62 (55.4%) and combined loco-regional and distant failure in 14 (12.5%) patients. Conclusion: Multiple involvement of mediastinal nodal stations for the pN2 NSCLC patients with PORT was a poor prognostic factor in this study. A prospective study is necessary to evaluate the N2 subclassification and to optimize the adjuvant treatment-
dc.description.statementOfResponsibilityopen-
dc.format.extent126~132-
dc.relation.isPartOfJournal of the Korean Society for Therapeutic Radiology and Oncology (대한방사선종양학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title비소세포성 폐암으로 수술 후 방사선치료가 시행된 N2병기 환자들에서 다발 부위 종격동 림프절 전이 여부에 따른 N2병기 구분의 임상적 의미-
dc.title.alternativeDivision of the N2 Stage According to the Multiplicity of the Involved Nodal Stations May be Necessary in the N2-NSCLC Patients Who are Treated with Postoperative Radiotherapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthor윤홍인-
dc.contributor.googleauthor김용배-
dc.contributor.googleauthor이창걸-
dc.contributor.googleauthor이익재-
dc.contributor.googleauthor김송이-
dc.contributor.googleauthor김준원-
dc.contributor.googleauthor김주항-
dc.contributor.googleauthor조병철-
dc.contributor.googleauthor이진구-
dc.contributor.googleauthor정경영-
dc.identifier.doi10.3857/jkstro.2009.27.3.126-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00945-
dc.contributor.localIdA03055-
dc.contributor.localIdA03225-
dc.contributor.localIdA03240-
dc.contributor.localIdA03571-
dc.contributor.localIdA03822-
dc.contributor.localIdA00744-
dc.relation.journalcodeJ01857-
dc.subject.keywordNon-small cell lung cancer-
dc.subject.keywordMediastinal nodal metastasis-
dc.subject.keywordPostoperative radiotherapy-
dc.subject.keywordMultiple station involvement-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.alternativeNameLee, Ik Jae-
dc.contributor.alternativeNameLee, Jin Gu-
dc.contributor.alternativeNameLee, Chang Geol-
dc.contributor.alternativeNameChung, Kyung Young-
dc.contributor.alternativeNameCho, Byoung Chul-
dc.contributor.alternativeNameKim, Yong Bae-
dc.contributor.affiliatedAuthorKim, Joo Hang-
dc.contributor.affiliatedAuthorLee, Ik Jae-
dc.contributor.affiliatedAuthorLee, Jin Gu-
dc.contributor.affiliatedAuthorLee, Chang Geol-
dc.contributor.affiliatedAuthorChung, Kyung Young-
dc.contributor.affiliatedAuthorCho, Byoung Chul-
dc.contributor.affiliatedAuthorKim, Yong Bae-
dc.citation.volume27-
dc.citation.number3-
dc.citation.startPage126-
dc.citation.endPage132-
dc.identifier.bibliographicCitationJournal of the Korean Society for Therapeutic Radiology and Oncology (대한방사선종양학회지), Vol.27(3) : 126-132, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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