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비소세포성 폐암으로 수술 후 방사선치료가 시행된 N2병기 환자들에서 다발 부위 종격동 림프절 전이 여부에 따른 N2병기 구분의 임상적 의미
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김주항 | - |
dc.contributor.author | 이익재 | - |
dc.contributor.author | 이진구 | - |
dc.contributor.author | 이창걸 | - |
dc.contributor.author | 정경영 | - |
dc.contributor.author | 조병철 | - |
dc.contributor.author | 김용배 | - |
dc.date.accessioned | 2015-04-24T17:02:40Z | - |
dc.date.available | 2015-04-24T17:02:40Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1229-8719 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104653 | - |
dc.description.abstract | Purpose: We wanted to evaluate the prognostic factors for the pathologic N2 non-small cell lung cancer (NSCLC) patients who were treated by postoperative radiotherapy. Materials and Methods: We retrospectively reviewed 112 pN2 NSCLC patients who underwent surgery and postoperative radiotherapy (PORT) From January 1999 to February 2008. Seventy-five (67%) patients received segmentectomy or lobectomy and 37 (33%) patients received pneumonectomy. the resection margin was negative in 94 patients, and it was positive or close in 18 patients. Chemotherapy was administered to 103 (92%) patients. Nine (8%) patients received PORT alone. the median radiation dose was 54 Gy (range, 45 to 66), and the fraction size was 1.8~2 Gy. Results: the 2-year overall survival (OS) rate was 60.2% and the disease free survival (DFS) rate was 44.7% for all the patients. Univariate analysis showed that the patients with multiple-station N2 disease had significantly reduced OS and DFS (p=0.047, p=0.007) and the patients with an advanced T stage (≥T3) had significantly reduced OS and DFS (p<0.001, p=0.025). A large tumor size (≥5 cm) and positive lymphovascular invasion reduced the OS (p=0.035, 0.034). Using multivariate analysis, we found that multiple-station N2 disease and an advanced T stage (≥T3) significantly reduced the OS and DFS. Seventy one patients (63.4%) had recurrence of disease. the patterns of failure were loco-regional in 23 (20.5%) patients, distant failure in 62 (55.4%) and combined loco-regional and distant failure in 14 (12.5%) patients. Conclusion: Multiple involvement of mediastinal nodal stations for the pN2 NSCLC patients with PORT was a poor prognostic factor in this study. A prospective study is necessary to evaluate the N2 subclassification and to optimize the adjuvant treatment | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 126~132 | - |
dc.language | Korean | - |
dc.publisher | 대한방사선종양학회 | - |
dc.relation.isPartOf | Journal of the Korean Society for Therapeutic Radiology and Oncology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 비소세포성 폐암으로 수술 후 방사선치료가 시행된 N2병기 환자들에서 다발 부위 종격동 림프절 전이 여부에 따른 N2병기 구분의 임상적 의미 | - |
dc.title.alternative | Division of the N2 Stage According to the Multiplicity of the Involved Nodal Stations May be Necessary in the N2-NSCLC Patients Who are Treated with Postoperative Radiotherapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학) | - |
dc.contributor.googleauthor | 윤홍인 | - |
dc.contributor.googleauthor | 김용배 | - |
dc.contributor.googleauthor | 이창걸 | - |
dc.contributor.googleauthor | 이익재 | - |
dc.contributor.googleauthor | 김송이 | - |
dc.contributor.googleauthor | 김준원 | - |
dc.contributor.googleauthor | 김주항 | - |
dc.contributor.googleauthor | 조병철 | - |
dc.contributor.googleauthor | 이진구 | - |
dc.contributor.googleauthor | 정경영 | - |
dc.identifier.doi | 10.3857/jkstro.2009.27.3.126 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00945 | - |
dc.contributor.localId | A03055 | - |
dc.contributor.localId | A03225 | - |
dc.contributor.localId | A03240 | - |
dc.contributor.localId | A03571 | - |
dc.contributor.localId | A03822 | - |
dc.contributor.localId | A00744 | - |
dc.relation.journalcode | J01857 | - |
dc.subject.keyword | Non-small cell lung cancer | - |
dc.subject.keyword | Mediastinal nodal metastasis | - |
dc.subject.keyword | Postoperative radiotherapy | - |
dc.subject.keyword | Multiple station involvement | - |
dc.contributor.alternativeName | Kim, Joo Hang | - |
dc.contributor.alternativeName | Lee, Ik Jae | - |
dc.contributor.alternativeName | Lee, Jin Gu | - |
dc.contributor.alternativeName | Lee, Chang Geol | - |
dc.contributor.alternativeName | Chung, Kyung Young | - |
dc.contributor.alternativeName | Cho, Byoung Chul | - |
dc.contributor.alternativeName | Kim, Yong Bae | - |
dc.contributor.affiliatedAuthor | Kim, Joo Hang | - |
dc.contributor.affiliatedAuthor | Lee, Ik Jae | - |
dc.contributor.affiliatedAuthor | Lee, Jin Gu | - |
dc.contributor.affiliatedAuthor | Lee, Chang Geol | - |
dc.contributor.affiliatedAuthor | Chung, Kyung Young | - |
dc.contributor.affiliatedAuthor | Cho, Byoung Chul | - |
dc.contributor.affiliatedAuthor | Kim, Yong Bae | - |
dc.citation.volume | 27 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 126 | - |
dc.citation.endPage | 132 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society for Therapeutic Radiology and Oncology, Vol.27(3) : 126-132, 2009 | - |
dc.identifier.rimsid | 52835 | - |
dc.type.rims | ART | - |
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