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Genetic polymorphism and haplotype analysis of 4 tightly linked X-STR duos in Koreans

DC Field Value Language
dc.contributor.author신경진-
dc.contributor.author심정은-
dc.contributor.author양우익-
dc.contributor.author이환영-
dc.contributor.author임은진-
dc.date.accessioned2015-04-24T17:02:03Z-
dc.date.available2015-04-24T17:02:03Z-
dc.date.issued2009-
dc.identifier.issn0353-9504-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104633-
dc.description.abstractAIM: To investigate genetic polymorphism and haplotypes of tightly linked X-chromosomal short tandem repeat (X-STR) clusters in Koreans. METHODS: Four X-STR duos in the linkage group 1-4 (DXS10135-DXS8378, DXS7132-DXS10074, HPRTB-DXS10101, and DXS10134-DXS7423) were investigated in 450 unrelated Koreans (300 men and 150 women) using the Mentype Argus X-8 Polymerase Chain Reaction Amplification Kit. RESULTS: No significant deviation from Hardy-Weinberg equilibrium was observed in any of the 8 loci. DXS10135 was the most polymorphic X-STRs, with 25 alleles and DXS7423 was the least informative, with 5 alleles. Eleven off-ladder alleles and a triallelic pattern were observed, and these alleles were characterized by cloning and sequencing analysis. In 300 Korean men, 38 to 59 haplotypes were observed for each linkage duo with 91.6-96.6% of haplotype diversities. However, due to the low genetic diversity of DXS7423, the X-STR duo in linkage group 4 (DXS10134-DXS7423), in comparison with other linkage duos, had considerably lower haplotype diversity values (91.6%) with 3 common haplotypes (35-15, 36-15, and 37-15) observed in 44.3% of Koreans. CONCLUSION: Four X-STR duos in the linkage group 1-4 will be able to provide a powerful tool for solving complex kinship cases in Koreans. However, to increase the haplotype diversity in the linkage group 4, it will be useful to discover a new marker for Asians that can serve as an adequate substitute for DXS7423 or at least complement the existing linkage duo of DXS10134-DXS7423-
dc.description.statementOfResponsibilityopen-
dc.format.extent305~312-
dc.relation.isPartOfCROATIAN MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAsian Continental Ancestry Group/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHGenes, X-Linked*-
dc.subject.MESHGenetic Linkage*-
dc.subject.MESHHaplotypes*-
dc.subject.MESHHumans-
dc.subject.MESHKorea-
dc.subject.MESHMale-
dc.subject.MESHMicrosatellite Repeats*-
dc.subject.MESHPolymerase Chain Reaction-
dc.subject.MESHPolymorphism, Genetic*-
dc.subject.MESHSequence Analysis, DNA-
dc.titleGenetic polymorphism and haplotype analysis of 4 tightly linked X-STR duos in Koreans-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorEun Jin Lim-
dc.contributor.googleauthorHwan Young Lee-
dc.contributor.googleauthorJeong Eun Sim-
dc.contributor.googleauthorWoo Ick Yang-
dc.contributor.googleauthorKyoung-Jin Shin-
dc.identifier.doi10.3325/cmj.2009.50.305-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02085-
dc.contributor.localIdA02210-
dc.contributor.localIdA02300-
dc.contributor.localIdA03335-
dc.contributor.localIdA03392-
dc.relation.journalcodeJ03130-
dc.identifier.eissn1332-8166-
dc.identifier.pmid19480025-
dc.contributor.alternativeNameShin, Kyoung Jin-
dc.contributor.alternativeNameSim, Jeong Eun-
dc.contributor.alternativeNameYang, Woo Ick-
dc.contributor.alternativeNameLee, Hwan Young-
dc.contributor.alternativeNameLim, Eun Jin-
dc.contributor.affiliatedAuthorShin, Kyoung Jin-
dc.contributor.affiliatedAuthorSim, Jeong Eun-
dc.contributor.affiliatedAuthorYang, Woo Ick-
dc.contributor.affiliatedAuthorLee, Hwan Young-
dc.contributor.affiliatedAuthorLim, Eun Jin-
dc.citation.volume50-
dc.citation.number3-
dc.citation.startPage305-
dc.citation.endPage312-
dc.identifier.bibliographicCitationCROATIAN MEDICAL JOURNAL, Vol.50(3) : 305-312, 2009-
dc.identifier.rimsid52825-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Forensic Medicine (법의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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