Cited 24 times in
Genetic polymorphism and haplotype analysis of 4 tightly linked X-STR duos in Koreans
DC Field | Value | Language |
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dc.contributor.author | 신경진 | - |
dc.contributor.author | 심정은 | - |
dc.contributor.author | 양우익 | - |
dc.contributor.author | 이환영 | - |
dc.contributor.author | 임은진 | - |
dc.date.accessioned | 2015-04-24T17:02:03Z | - |
dc.date.available | 2015-04-24T17:02:03Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0353-9504 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104633 | - |
dc.description.abstract | AIM: To investigate genetic polymorphism and haplotypes of tightly linked X-chromosomal short tandem repeat (X-STR) clusters in Koreans. METHODS: Four X-STR duos in the linkage group 1-4 (DXS10135-DXS8378, DXS7132-DXS10074, HPRTB-DXS10101, and DXS10134-DXS7423) were investigated in 450 unrelated Koreans (300 men and 150 women) using the Mentype Argus X-8 Polymerase Chain Reaction Amplification Kit. RESULTS: No significant deviation from Hardy-Weinberg equilibrium was observed in any of the 8 loci. DXS10135 was the most polymorphic X-STRs, with 25 alleles and DXS7423 was the least informative, with 5 alleles. Eleven off-ladder alleles and a triallelic pattern were observed, and these alleles were characterized by cloning and sequencing analysis. In 300 Korean men, 38 to 59 haplotypes were observed for each linkage duo with 91.6-96.6% of haplotype diversities. However, due to the low genetic diversity of DXS7423, the X-STR duo in linkage group 4 (DXS10134-DXS7423), in comparison with other linkage duos, had considerably lower haplotype diversity values (91.6%) with 3 common haplotypes (35-15, 36-15, and 37-15) observed in 44.3% of Koreans. CONCLUSION: Four X-STR duos in the linkage group 1-4 will be able to provide a powerful tool for solving complex kinship cases in Koreans. However, to increase the haplotype diversity in the linkage group 4, it will be useful to discover a new marker for Asians that can serve as an adequate substitute for DXS7423 or at least complement the existing linkage duo of DXS10134-DXS7423 | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 305~312 | - |
dc.relation.isPartOf | CROATIAN MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Asian Continental Ancestry Group/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genes, X-Linked* | - |
dc.subject.MESH | Genetic Linkage* | - |
dc.subject.MESH | Haplotypes* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microsatellite Repeats* | - |
dc.subject.MESH | Polymerase Chain Reaction | - |
dc.subject.MESH | Polymorphism, Genetic* | - |
dc.subject.MESH | Sequence Analysis, DNA | - |
dc.title | Genetic polymorphism and haplotype analysis of 4 tightly linked X-STR duos in Koreans | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Eun Jin Lim | - |
dc.contributor.googleauthor | Hwan Young Lee | - |
dc.contributor.googleauthor | Jeong Eun Sim | - |
dc.contributor.googleauthor | Woo Ick Yang | - |
dc.contributor.googleauthor | Kyoung-Jin Shin | - |
dc.identifier.doi | 10.3325/cmj.2009.50.305 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02085 | - |
dc.contributor.localId | A02210 | - |
dc.contributor.localId | A02300 | - |
dc.contributor.localId | A03335 | - |
dc.contributor.localId | A03392 | - |
dc.relation.journalcode | J03130 | - |
dc.identifier.eissn | 1332-8166 | - |
dc.identifier.pmid | 19480025 | - |
dc.contributor.alternativeName | Shin, Kyoung Jin | - |
dc.contributor.alternativeName | Sim, Jeong Eun | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.alternativeName | Lee, Hwan Young | - |
dc.contributor.alternativeName | Lim, Eun Jin | - |
dc.contributor.affiliatedAuthor | Shin, Kyoung Jin | - |
dc.contributor.affiliatedAuthor | Sim, Jeong Eun | - |
dc.contributor.affiliatedAuthor | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | Lee, Hwan Young | - |
dc.contributor.affiliatedAuthor | Lim, Eun Jin | - |
dc.citation.volume | 50 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 305 | - |
dc.citation.endPage | 312 | - |
dc.identifier.bibliographicCitation | CROATIAN MEDICAL JOURNAL, Vol.50(3) : 305-312, 2009 | - |
dc.identifier.rimsid | 52825 | - |
dc.type.rims | ART | - |
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