Cited 9 times in
Non-ischaemic titrated cardiac injury caused by radiofrequency catheter ablation of atrial fibrillation mobilizes CD34-positive mononuclear cells by non-stromal cell-derived factor-1alpha mechanism
DC Field | Value | Language |
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dc.contributor.author | 박희남 | - |
dc.date.accessioned | 2015-04-24T16:58:57Z | - |
dc.date.available | 2015-04-24T16:58:57Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1099-5129 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104537 | - |
dc.description.abstract | AIMS: It has been known that myocardial ischaemia mobilizes CD34+ bone marrow-derived cells by the stromal cell-derived factor (SDF)-1alpha pathway. We hypothesized that non-ischaemic titrated cardiac injury caused by radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) recruits CD34+ cells by an alternative mechanism. METHODS AND RESULTS: Fifty-six patients (39 males, 53.0 +/- 13.5 years old) who underwent electrophysiology study (EPS; n = 10) or RFCA of AF (n = 46) were included. Peripheral blood CD34+ cell count and multiple serologic markers were evaluated before, immediately after, at 24 h, and 10 days after the procedure. The results are as follows: (i) the per cent increase in CD34+ cells (%DeltaCD34+) was significant after RFCA compared with after EPS (P < 0.01), and correlated with RF duration and troponin I, respectively. (ii) In contrast, SDF-1alpha decreased after RFCA and had no correlation with %DeltaCD34+ cells while matrix metalloproteinase (MMP)-9 (P < 0.0001) and GRObeta (P < 0.001) increased after RFCA and had correlations with 24 h %DeltaCD34+ cells. CONCLUSION: Non-ischaemic titrated cardiac injury caused by AF ablation mobilizes CD34+ cells to the peripheral blood through a non-SDF-1alpha pathway associated with MMP-9 and GRObeta. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1024~1031 | - |
dc.relation.isPartOf | EUROPACE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antigens, CD34/immunology* | - |
dc.subject.MESH | Atrial Fibrillation/immunology* | - |
dc.subject.MESH | Atrial Fibrillation/surgery* | - |
dc.subject.MESH | Catheter Ablation/adverse effects* | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Chemokine CXCL12/immunology | - |
dc.subject.MESH | Chemokine CXCL2/immunology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Heart Injuries/etiology* | - |
dc.subject.MESH | Heart Injuries/immunology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Matrix Metalloproteinase 9/immunology | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myocardial Ischemia/etiology | - |
dc.subject.MESH | Myocardial Ischemia/immunology | - |
dc.subject.MESH | T-Lymphocytes/immunology* | - |
dc.title | Non-ischaemic titrated cardiac injury caused by radiofrequency catheter ablation of atrial fibrillation mobilizes CD34-positive mononuclear cells by non-stromal cell-derived factor-1alpha mechanism | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Sook Kyoung Kim | - |
dc.contributor.googleauthor | Hui-Nam Pak | - |
dc.contributor.googleauthor | Jae Hyung Park | - |
dc.contributor.googleauthor | Jong Il Choi | - |
dc.contributor.googleauthor | Myung-Hyun Nam | - |
dc.contributor.googleauthor | Yunjung Jo | - |
dc.contributor.googleauthor | Young-Hoon Kim | - |
dc.identifier.doi | 10.1093/europace/eup185 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01776 | - |
dc.relation.journalcode | J00801 | - |
dc.identifier.eissn | 1532-2092 | - |
dc.identifier.pmid | 19589793 | - |
dc.subject.keyword | CD34þ mononuclear cell | - |
dc.subject.keyword | Atrial fibrillation | - |
dc.subject.keyword | Catheter ablation | - |
dc.subject.keyword | Cardiac injury | - |
dc.contributor.alternativeName | Pak, Hui Nam | - |
dc.contributor.affiliatedAuthor | Pak, Hui Nam | - |
dc.citation.volume | 11 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1024 | - |
dc.citation.endPage | 1031 | - |
dc.identifier.bibliographicCitation | EUROPACE, Vol.11(8) : 1024-1031, 2009 | - |
dc.identifier.rimsid | 51097 | - |
dc.type.rims | ART | - |
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