Enlargement of the foveal avascular zone in diabetic retinopathy after adjunctive intravitreal bevacizumab (avastin) with pars plana vitrectomy

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Citation: JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, Vol.25(2) : 173-174, 2009

MeSH: Adult ; Angiogenesis Inhibitors/adverse effects* ; Angiogenesis Inhibitors/therapeutic use ; Antibodies, Monoclonal/adverse effects* ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Bevacizumab ; Combined Modality Therapy ; Diabetic Retinopathy/drug therapy* ; Diabetic Retinopathy/surgery ; Fluorescein Angiography ; Fovea Centralis/blood supply ; Fovea Centralis/pathology* ; Humans ; Hypertrophy ; Injections ; Male ; Vitrectomy ; Vitreous Body ; Vitreous Hemorrhage/drug therapy* ; Vitreous Hemorrhage/surgery

Abstract: PURPOSE: The aim of this study was to describe a case of angiographically documented foveal avascular zone (FAZ) enlargement after intravitreal bevacizumab following vitrectomy and intravitreal bevacizumab treatment of a diabetic patient.

METHODS: This study was done as a case report.

RESULTS: A 40-year-old diabetic man was treated with a pars plana vitrectomy and intravitreal bevacizumab for a nonclearing vitreous hemorrhage. Despite successful surgery, the postoperative best-corrected visual acuity was not improved. FAZ area had increased from 1.48 mm(2) preoperatively to 1.96 mm(2) postoperatively (24.5% increase).

CONCLUSIONS: Although intravitreal bevacizumab is an effective modality for diabetic retinopathy, it may deteriorate pre-existing retinal ischemia

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

Yonsei Authors: Koh, Hyoung Jun(고형준) https://orcid.org/0000-0002-5932-8516
Lee, Sung Jun(이성준)

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YUHSpace: Enlargement of the foveal avascular zone in diabetic retinopathy after adjunctive intravitreal bevacizumab (avastin) with pars plana vitrectomy