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Concentration of cytokines in the aqueous humor of patients with naive, recurrent and regressed CNV associated with amd after bevacizumab treatment

Authors
 MI IN ROH  ;  HONG SUK KIM  ;  JI HUN SONG  ;  JONG BAEK LIM  ;  HYOUNG JUN KOH  ;  OH WOONG KWON 
Citation
 RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, Vol.29(4) : 523-529, 2009 
Journal Title
 RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES 
ISSN
 0275-004X 
Issue Date
2009
MeSH
Aged ; Angiogenesis Inhibitors/therapeutic use* ; Antibodies, Monoclonal/therapeutic use* ; Antibodies, Monoclonal, Humanized ; Aqueous Humor/metabolism* ; Bevacizumab ; Choroidal Neovascularization/etiology ; Choroidal Neovascularization/metabolism* ; Choroidal Neovascularization/physiopathology ; Choroidal Neovascularization/prevention & control ; Cytokines/metabolism* ; Female ; Humans ; Interleukin-2/metabolism ; Interleukin-6/metabolism ; Interleukin-8/metabolism ; Macular Degeneration/complications ; Macular Degeneration/drug therapy* ; Macular Degeneration/metabolism* ; Male ; Middle Aged ; Osmolar Concentration ; Recurrence ; Tumor Necrosis Factor-alpha/metabolism ; Vascular Endothelial Growth Factor A/antagonists & inhibitors
Abstract
PURPOSE: : To evaluate the concentration of various cytokines in the aqueous humor of patients with naive, recurrent, and regressed choroidal neovascularization (CNV) of age-related macular degeneration after bevacizumab treatment. METHODS: : Aqueous humor samples were collected from 36 eyes with age-related macular degeneration and 10 controls during cataract surgery. Of 36 patients with age-related macular degeneration, 5 eyes were naïve to bevacizumab injection, 14 eyes had recurrent CNV after bevacizumab treatment, and 17 eyes had regressed CNV after bevacizumab treatment. Cytokines were measured by an immunoassay using multianalyte biochip array technology (Evidence investigator cytokine and growth factor biochip array, RANDOX laboratories Ltd., Crumlin, UK). RESULTS: : No significant difference in the cytokine levels was noted between the control group and the naïve CNV group (all P > 0.05). Vascular endothelial growth factor in both naive (66.8 +/- 35.1 pg/mL) and recurrent CNV groups (55.7 +/- 63.0 pg/mL) was significantly higher compared with regressed CNV group (9.8 +/- 12.8 pg/mL, P = 0.025 and P = 0.004, respectively) but was not statistically different from the control group (81.8 +/- 43.7 pg/mL, P = 0.310 and P = 0.212, respectively). The aqueous humor level of tumor necrosis factor-alpha and interleukin (IL)-2 was significantly lower in recurrent CNV group (P = 0.036 and P = 0.019) compared with the control group. In the active CNV patients (recurrent and naïve CNV groups), the aqueous humor levels of IL-6 and IL-8 significantly correlated with the size of CNV (rho = 0.692, P = 0.001 and rho = 0.745, P < 0.001, respectively). CONCLUSION: : Levels of Vascular endothelial growth factor measured in the aqueous humor were significantly related to the disease activity of CNV in age-related macular degeneration. Moreover, IL-2, IL-6, IL-8, and tumor necrosis factor-alpha may be related to the activity of CNV
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006982-200904000-00015&LSLINK=80&D=ovft
DOI
10.1097/IAE.0b013e318195cb15
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hyoung Jun(고형준) ORCID logo https://orcid.org/0000-0002-5932-8516
Kwon, Oh Woong(권오웅)
Roh, Mi In(노미인)
Song, Ji Hun(송지훈)
Lim, Jong Baeck(임종백) ORCID logo https://orcid.org/0000-0003-0419-0422
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104482
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