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A randomized controlled study of sequentially applied repetitive transcranial magnetic stimulation in obsessive-compulsive disorder.

DC FieldValueLanguage
dc.contributor.author강지인-
dc.contributor.author김세주-
dc.contributor.author김찬형-
dc.contributor.author남궁기-
dc.date.accessioned2015-04-24T16:56:56Z-
dc.date.available2015-04-24T16:56:56Z-
dc.date.issued2009-
dc.identifier.issn0160-6689-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104473-
dc.description.abstractOBJECTIVE: The present study investigated possible therapeutic effects and safety of sequentially combined low-frequency repetitive transcranial magnetic stimulation (rTMS) to the right dorsolateral prefrontal cortex and supplementary motor area in patients with treatment-resistant obsessive-compulsive disorder. METHOD: Between February 2007 and January 2008, we carried out a study with a rater-blinded, sham-controlled design in which 20 patients with treatment-resistant obsessive-compulsive disorder, confirmed by a psychiatrist after use of the Structured Clinical Interview for DSM-IV Axis I Disorders-Clinician Version, were randomly assigned to either active rTMS (n = 10) or sham treatment (n = 10). Over 10 days, rTMS of 1 Hz was given at 110% of the motor threshold for 20 minutes over the right dorsolateral prefrontal cortex and sequentially at 1 Hz at 100% of the motor threshold for 20 minutes over the supplementary motor area. The primary outcome measure was the Yale-Brown Obsessive Compulsive Scale (YBOCS) score. RESULTS: For the between-group analyses, there were no significant differences over 4 weeks between the active and sham groups on the YBOCS (F = 0.01, P = .92) and the Montgomery-Asberg Depression Rating Scale (MADRS; F = 0.39, P = .54). In repeated-measures analyses on all subjects, there was a significant effect of time on the YBOCS (F = 5.48, P = .009) and the MADRS (F = 6.55, P = .004). There were no significant group-by-time interactions for the YBOCS (F = 0.03, P = .94) or the MADRS (F = 0.09, P = .67). CONCLUSIONS: These findings suggest that 10 sessions of sequential rTMS of the right dorsolateral prefrontal cortex and the supplementary motor area at low frequency had no therapeutic effect on obsessive-compulsive symptoms. However, rTMS was a safe method of treatment, and there was no significant change in cognitive function after rTMS. Further controlled studies using a more sophisticated sham system in larger samples are required to confirm the effect of rTMS in obsessive-compulsive disorder.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1645~1651-
dc.relation.isPartOfJournal of Clinical Psychiatry-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHFemale-
dc.subject.MESHFunctional Laterality/physiology-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHObsessive-Compulsive Disorder/diagnosis-
dc.subject.MESHObsessive-Compulsive Disorder/therapy*-
dc.subject.MESHOutcome Assessment (Health Care)-
dc.subject.MESHPrefrontal Cortex/physiology-
dc.subject.MESHPsychiatric Status Rating Scales-
dc.subject.MESHTranscranial Magnetic Stimulation/methods*-
dc.subject.MESHTreatment Outcome-
dc.titleA randomized controlled study of sequentially applied repetitive transcranial magnetic stimulation in obsessive-compulsive disorder.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학)-
dc.contributor.googleauthorJee In Kang-
dc.contributor.googleauthorChan-Hyung Kim-
dc.contributor.googleauthorKee Namkoong-
dc.contributor.googleauthorChang-il Lee-
dc.contributor.googleauthorSe Joo Kim-
dc.identifier.doi10.4088/JCP.08m04500-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00084-
dc.contributor.localIdA00604-
dc.contributor.localIdA01036-
dc.contributor.localIdA01240-
dc.relation.journalcodeJ01339-
dc.identifier.pmid19709504-
dc.identifier.urlhttp://www.psychiatrist.com/jcp/article/Pages/2009/v70n12/v70n1204.aspx-
dc.contributor.alternativeNameKang, Jee In-
dc.contributor.alternativeNameKim, Se Joo-
dc.contributor.alternativeNameKim, Chan Hyung-
dc.contributor.alternativeNameNamkoong, Kee-
dc.contributor.affiliatedAuthorKang, Jee In-
dc.contributor.affiliatedAuthorKim, Se Joo-
dc.contributor.affiliatedAuthorKim, Chan Hyung-
dc.contributor.affiliatedAuthorNamkoong, Kee-
dc.citation.volume70-
dc.citation.number12-
dc.citation.startPage1645-
dc.citation.endPage1651-
dc.identifier.bibliographicCitationJournal of Clinical Psychiatry, Vol.70(12) : 1645-1651, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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