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A randomized controlled study of sequentially applied repetitive transcranial magnetic stimulation in obsessive-compulsive disorder.
DC Field | Value | Language |
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dc.contributor.author | 강지인 | - |
dc.contributor.author | 김세주 | - |
dc.contributor.author | 김찬형 | - |
dc.contributor.author | 남궁기 | - |
dc.date.accessioned | 2015-04-24T16:56:56Z | - |
dc.date.available | 2015-04-24T16:56:56Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0160-6689 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104473 | - |
dc.description.abstract | OBJECTIVE: The present study investigated possible therapeutic effects and safety of sequentially combined low-frequency repetitive transcranial magnetic stimulation (rTMS) to the right dorsolateral prefrontal cortex and supplementary motor area in patients with treatment-resistant obsessive-compulsive disorder. METHOD: Between February 2007 and January 2008, we carried out a study with a rater-blinded, sham-controlled design in which 20 patients with treatment-resistant obsessive-compulsive disorder, confirmed by a psychiatrist after use of the Structured Clinical Interview for DSM-IV Axis I Disorders-Clinician Version, were randomly assigned to either active rTMS (n = 10) or sham treatment (n = 10). Over 10 days, rTMS of 1 Hz was given at 110% of the motor threshold for 20 minutes over the right dorsolateral prefrontal cortex and sequentially at 1 Hz at 100% of the motor threshold for 20 minutes over the supplementary motor area. The primary outcome measure was the Yale-Brown Obsessive Compulsive Scale (YBOCS) score. RESULTS: For the between-group analyses, there were no significant differences over 4 weeks between the active and sham groups on the YBOCS (F = 0.01, P = .92) and the Montgomery-Asberg Depression Rating Scale (MADRS; F = 0.39, P = .54). In repeated-measures analyses on all subjects, there was a significant effect of time on the YBOCS (F = 5.48, P = .009) and the MADRS (F = 6.55, P = .004). There were no significant group-by-time interactions for the YBOCS (F = 0.03, P = .94) or the MADRS (F = 0.09, P = .67). CONCLUSIONS: These findings suggest that 10 sessions of sequential rTMS of the right dorsolateral prefrontal cortex and the supplementary motor area at low frequency had no therapeutic effect on obsessive-compulsive symptoms. However, rTMS was a safe method of treatment, and there was no significant change in cognitive function after rTMS. Further controlled studies using a more sophisticated sham system in larger samples are required to confirm the effect of rTMS in obsessive-compulsive disorder. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1645~1651 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL PSYCHIATRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Functional Laterality/physiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Obsessive-Compulsive Disorder/diagnosis | - |
dc.subject.MESH | Obsessive-Compulsive Disorder/therapy* | - |
dc.subject.MESH | Outcome Assessment (Health Care) | - |
dc.subject.MESH | Prefrontal Cortex/physiology | - |
dc.subject.MESH | Psychiatric Status Rating Scales | - |
dc.subject.MESH | Transcranial Magnetic Stimulation/methods* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | A randomized controlled study of sequentially applied repetitive transcranial magnetic stimulation in obsessive-compulsive disorder. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | Jee In Kang | - |
dc.contributor.googleauthor | Chan-Hyung Kim | - |
dc.contributor.googleauthor | Kee Namkoong | - |
dc.contributor.googleauthor | Chang-il Lee | - |
dc.contributor.googleauthor | Se Joo Kim | - |
dc.identifier.doi | 10.4088/JCP.08m04500 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00084 | - |
dc.contributor.localId | A00604 | - |
dc.contributor.localId | A01036 | - |
dc.contributor.localId | A01240 | - |
dc.relation.journalcode | J01339 | - |
dc.identifier.eissn | 1555-2101 | - |
dc.identifier.pmid | 19709504 | - |
dc.identifier.url | http://www.psychiatrist.com/jcp/article/Pages/2009/v70n12/v70n1204.aspx | - |
dc.contributor.alternativeName | Kang, Jee In | - |
dc.contributor.alternativeName | Kim, Se Joo | - |
dc.contributor.alternativeName | Kim, Chan Hyung | - |
dc.contributor.alternativeName | Namkoong, Kee | - |
dc.contributor.affiliatedAuthor | Kang, Jee In | - |
dc.contributor.affiliatedAuthor | Kim, Se Joo | - |
dc.contributor.affiliatedAuthor | Kim, Chan Hyung | - |
dc.contributor.affiliatedAuthor | Namkoong, Kee | - |
dc.citation.volume | 70 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1645 | - |
dc.citation.endPage | 1651 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL PSYCHIATRY, Vol.70(12) : 1645-1651, 2009 | - |
dc.identifier.rimsid | 54147 | - |
dc.type.rims | ART | - |
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