Cited 19 times in
Interaction between serotonin transporter promoter and dopamine receptor D4 polymorphisms on decision making
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강지인 | - |
dc.contributor.author | 김세주 | - |
dc.contributor.author | 남궁기 | - |
dc.date.accessioned | 2015-04-24T16:56:48Z | - |
dc.date.available | 2015-04-24T16:56:48Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0278-5846 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104469 | - |
dc.description.abstract | Appropriate decision making is an important brain function to maintain our lives. The Iowa gambling task (IGT) is a tool for decision making under ambiguity. The aims of this study were to evaluate the influence of serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) polymorphisms and their interaction on IGT performance. One hundred fifty-nine normal subjects were involved in this study. All subjects performed the IGT and were genotyped for the triallelic 5-HTTLPR and DRD4 48 bp uVNTR polymorphisms. After controlling for gender, age, and impulsiveness, there were no main effects of 5-HTTLPR and DRD4 gene polymorphisms on total IGT score. However, there was a significant effect on the interaction between 5-HTTLPR and DRD4 on total IGT score. In the presence of the 5-HTTLPR S'S' (SS+SL(G)+L(G)L(G)), subjects with the DRD4 2R+ (2 repeat carrier) had higher total IGT score compared to those with the DRD4 2R-. In contrast, in the absence of the 5-HTTLPR S'S', subjects with the DRD4 2R- had higher total IGT score than those with the DRD4 2R+. When we divided IGT scores into the first and second half of trials, the 5-HTTLPRxDRD4 interaction effects were stronger in the second half block (decision under risk) than in the first half block (decision under ambiguity). In conclusion, the DRD4 genotypes might influence decision-making performance differently according to the background genotypes of 5-HTTLPR. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1217~1222 | - |
dc.relation.isPartOf | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Decision Making/physiology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gambling | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Impulsive Behavior/genetics | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neuropsychological Tests | - |
dc.subject.MESH | Polymorphism, Single Nucleotide/genetics* | - |
dc.subject.MESH | Promoter Regions, Genetic/genetics* | - |
dc.subject.MESH | Psychiatric Status Rating Scales | - |
dc.subject.MESH | Receptors, Dopamine D4/genetics* | - |
dc.subject.MESH | Serotonin Plasma Membrane Transport Proteins/genetics* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Interaction between serotonin transporter promoter and dopamine receptor D4 polymorphisms on decision making | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | Ra Yeon Ha | - |
dc.contributor.googleauthor | Kee Namkoong | - |
dc.contributor.googleauthor | Jee In Kang | - |
dc.contributor.googleauthor | Yang Tae Kim | - |
dc.contributor.googleauthor | Se Joo Kim | - |
dc.identifier.doi | 10.1016/j.pnpbp.2009.07.009 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00084 | - |
dc.contributor.localId | A00604 | - |
dc.contributor.localId | A01240 | - |
dc.relation.journalcode | J02554 | - |
dc.identifier.eissn | 1878-4216 | - |
dc.identifier.pmid | 19615421 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0278584609002176 | - |
dc.subject.keyword | Decision making | - |
dc.subject.keyword | Dopamine receptor D4 polymorphism | - |
dc.subject.keyword | Iowa gambling task | - |
dc.subject.keyword | Serotonin transporter linked polymorphic region | - |
dc.contributor.alternativeName | Kang, Jee In | - |
dc.contributor.alternativeName | Kim, Se Joo | - |
dc.contributor.alternativeName | Namkoong, Kee | - |
dc.contributor.affiliatedAuthor | Kang, Jee In | - |
dc.contributor.affiliatedAuthor | Kim, Se Joo | - |
dc.contributor.affiliatedAuthor | Namkoong, Kee | - |
dc.citation.volume | 33 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1217 | - |
dc.citation.endPage | 1222 | - |
dc.identifier.bibliographicCitation | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, Vol.33(7) : 1217-1222, 2009 | - |
dc.identifier.rimsid | 54143 | - |
dc.type.rims | ART | - |
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