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Effect of low dose ketamine to prevent remifentanil-induced cough: a randomized, double-blind, placebo controlled trial
DC Field | Value | Language |
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dc.contributor.author | 김지영 | - |
dc.date.accessioned | 2015-04-24T16:56:37Z | - |
dc.date.available | 2015-04-24T16:56:37Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 2005-6419 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104463 | - |
dc.description.abstract | BACKGROUND: A reflex cough is often observed after an intravenous (IV) bolus of remifentanil. Since ketamine was reported to be effective in modulating the cough reflex, this prospective, randomized, double-blind, placebo-controlled study was designed to evaluate the efficacy of pretreatment with ketamine on remifentanil-induced cough. METHODS: 320 patients undergoing general anesthesia for elective surgery were randomly allocated into two groups to receive either IV ketamine 0.1 mg/kg (ketamine group, n = 156) or 0.9% saline (saline group, n = 154) 1 min before administration of remifentanil at a target effect-site concentration of 5 ng/ml. Severity of cough was graded (mild, 1-2; moderate, 3-4; and severe, 5 or >5). RESULTS: The overall incidence of cough was significantly higher in the saline group (43/154 patients; 0.28, 95% CI 0.21, 0.36) than that in the ketamine group (18/156 patients; 0.12, 95% CI 0.07, 0.18) (P < 0.001). However, there was no significant difference in the severity and the onset time of cough between the groups. CONCLUSIONS: IV ketamine 0.1 mg/kg one minute before remifentanil was effective in suppressing remifentanil-induced cough without affecting the severity and onset time. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 624~627 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF ANESTHESIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effect of low dose ketamine to prevent remifentanil-induced cough: a randomized, double-blind, placebo controlled trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Ji Young Kim | - |
dc.contributor.googleauthor | Jong-Yeop Kim | - |
dc.contributor.googleauthor | Sung Yong Park | - |
dc.contributor.googleauthor | Wol Seon Jung | - |
dc.contributor.googleauthor | Hyun-Jeong Kwak | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00977 | - |
dc.relation.journalcode | J01963 | - |
dc.identifier.eissn | 2005-7563 | - |
dc.subject.keyword | Ketamine | - |
dc.subject.keyword | Opioid-induced cough | - |
dc.subject.keyword | Remifentanil | - |
dc.contributor.alternativeName | Kim, Ji Young | - |
dc.contributor.affiliatedAuthor | Kim, Ji Young | - |
dc.citation.volume | 56 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 624 | - |
dc.citation.endPage | 627 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF ANESTHESIOLOGY, Vol.56(6) : 624-627, 2009 | - |
dc.identifier.rimsid | 54137 | - |
dc.type.rims | ART | - |
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