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Synthesis of gold nanorod-embedded polymeric nanoparticles by a nanoprecipitation method for use as photothermal agents

Authors
 Eunjung Kim  ;  Jaemoon Yang  ;  Jihye Choi  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 NANOTECHNOLOGY, Vol.20(36) : 365602, 2009 
Journal Title
NANOTECHNOLOGY
ISSN
 0957-4484 
Issue Date
2009
MeSH
Biocompatible Materials/chemistry ; Chemical Precipitation ; Gold/chemistry* ; Metal Nanoparticles/chemistry* ; Microscopy, Electron, Transmission ; Nanotechnology/methods* ; Photochemical Processes ; Polyesters/chemistry* ; Spectroscopy, Fourier Transform Infrared ; Spectroscopy, Near-Infrared ; Temperature
Abstract
For the synthesis of biocompatible photothermal agents, gold nanorod-embedded polymeric nanoparticles (GPNs) were synthesized using a nanoprecipitation method. Uniform gold nanorods (GNRs), which are sensitive to a photothermal effect by near-infrared (NIR) light, with an aspect ratio of 4.0 were synthesized by a seed-mediated growth method. The hydroxyl groups of polycaprolactone diol (PCL diOH) were modified by esterification with mercaptopropionic acid to give a dithiol (polycaprolactone dithiol, PCL diSH) as a phase transfer and capping agent. Subsequently, hexadecyltrimethylammonium bromide (CTAB), a stabilizer of GNRs, was exchanged and/or removed by PCL diSH. PCL diSH-coated GNRs were further wrapped in a hydrophilic polymer, Pluronic F127, as a stabilizer. These newly formulated GPNs exhibit excellent stability in water and a maximum absorbance in the NIR region indicating a highly efficient surface plasmon resonance effect, phenomena useful for photothermal agents
Full Text
http://iopscience.iop.org/0957-4484/20/36/365602/
DOI
10.1088/0957-4484/20/36/365602
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104459
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