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Accumulation of plasmid-mediated fluoroquinolone resistance genes, qepA and qnrS1, in Enterobacter aerogenes co-producing RmtB and class A beta-lactamase LAP-1
DC Field | Value | Language |
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dc.contributor.author | 이경원 | - |
dc.date.accessioned | 2015-04-24T16:55:56Z | - |
dc.date.available | 2015-04-24T16:55:56Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0091-7370 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104442 | - |
dc.description.abstract | A new plasmid-mediated fluoroquinolone efflux pump gene, qepA, is known to be associated with the rmtB gene, which confers high-level resistance to aminoglycosides. We investigated the qepA gene in 573 AmpC-producing Enterobacteriaceae including one Citrobacter freundii known to harbor rmtB. Of them, two clonally unrelated E. aerogenes harbored qepA. Both isolates co-harbored rmtB, qnrS1, qepA, and bla(LAP-1) on an IncFI type plasmid. The qepA was flanked by two copies of IS26 containing ISCR3C, tnpA, tnpR, bla(TEM), and rmtB. The qnrS1 and bla(LAP-1) were located upstream of qepA. All the resistance determinants (qepA, qnrS1, rmtB, and bla(LAP-1)) were co-transferred to E. coli J53 by filter mating from both isolates. Although the prevalence of qepA is currently low, considering the presence of ISCR3C and the possibility of co-selection and co-transferability of plasmids, more active surveillance for these multi-drug resistant bacteria and prudent use of antimicrobials are needed. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 55~59 | - |
dc.relation.isPartOf | ANNALS OF CLINICAL AND LABORATORY SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anti-Bacterial Agents/pharmacology | - |
dc.subject.MESH | Conjugation, Genetic/drug effects | - |
dc.subject.MESH | Drug Resistance, Bacterial/drug effects | - |
dc.subject.MESH | Drug Resistance, Bacterial/genetics* | - |
dc.subject.MESH | Enterobacter aerogenes/drug effects | - |
dc.subject.MESH | Enterobacter aerogenes/enzymology* | - |
dc.subject.MESH | Enterobacter aerogenes/genetics* | - |
dc.subject.MESH | Fluoroquinolones/pharmacology* | - |
dc.subject.MESH | Genes, Bacterial* | - |
dc.subject.MESH | Microbial Sensitivity Tests | - |
dc.subject.MESH | Plasmids/genetics* | - |
dc.subject.MESH | beta-Lactamases/metabolism* | - |
dc.title | Accumulation of plasmid-mediated fluoroquinolone resistance genes, qepA and qnrS1, in Enterobacter aerogenes co-producing RmtB and class A beta-lactamase LAP-1 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Yeon-Joon Park | - |
dc.contributor.googleauthor | Jin Kyung Yu | - |
dc.contributor.googleauthor | Sang-Il Kim | - |
dc.contributor.googleauthor | Kyungwon Lee | - |
dc.contributor.googleauthor | Yoshichika Arakawa | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02649 | - |
dc.relation.journalcode | J00155 | - |
dc.identifier.eissn | 1550-8080 | - |
dc.identifier.pmid | 19201742 | - |
dc.identifier.url | http://www.annclinlabsci.org/content/39/1/55.long | - |
dc.contributor.alternativeName | Lee, Kyung Won | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Won | - |
dc.citation.volume | 39 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 55 | - |
dc.citation.endPage | 59 | - |
dc.identifier.bibliographicCitation | ANNALS OF CLINICAL AND LABORATORY SCIENCE, Vol.39(1) : 55-59, 2009 | - |
dc.identifier.rimsid | 54119 | - |
dc.type.rims | ART | - |
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