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노인에서 혈청 Cystatin C 농도를 이용한 반코마이신 투여용량 평가
DC Field | Value | Language |
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dc.contributor.author | 김준명 | - |
dc.contributor.author | 김창오 | - |
dc.contributor.author | 송영구 | - |
dc.contributor.author | 진성준 | - |
dc.contributor.author | 최준용 | - |
dc.date.accessioned | 2015-04-24T16:55:01Z | - |
dc.date.available | 2015-04-24T16:55:01Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1598-8112 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104414 | - |
dc.description.abstract | BACKGROUND: It has been suggested that the glomerular filtration rate can be predicted on the basis of serum cystatin C concentration. The aim of this study was to investigate the clinical utility of serum cystatin C as a marker of renal function and to evaluate the effect of an initial dose of vancomycin using serum cystatin C concentration in elderly patients. MATERIALS AND METHODS: Data was collected from July 2006 to September 2008. The subjects were elderly patients (> or =60-years-of-age; n=number of patients) who had been treated with vancomycin. Serum concentrations of parameters including vancomycin, creatinine, and cystatin C were measured. Correlations between measured vancomycin concentrations and predicted vancomycin concentrations based on serum cystatin C or serum creatinine were compared, and the initial dose setting of vancomycin on the basis of serum cystatin C concentration was evaluated. RESULTS: Serum cystatin C was a good marker of renal function in comparison with serum creatinine for various doses of vancomycin in the elderly subject. In subpopulation (n=88) with normal serum cystatin C level (< or =1.2 mg/L) who were treated with routine adult vancomycin dose (1g q 12 hours), vancomycin concentration was within the therapeutic range (5-15 mg/L) in 68 patients (77.3%), and was <20 mg/L in 77 of the 88 patients (88.5 %). CONCLUSIONS: Predictive prowess of serum vancomycin concentrations on the basis of the serum cystatin C concentration could be better than that based on the serum creatinine concentration in elderly patients | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 224~229 | - |
dc.relation.isPartOf | INFECTION AND CHEMOTHERAPY (감염과 화학요법) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 노인에서 혈청 Cystatin C 농도를 이용한 반코마이신 투여용량 평가 | - |
dc.title.alternative | Evaluation of the Effect of Initial dose of Vancomycin using Serum Cystatin C as a Marker in Elderly Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | 진성준 | - |
dc.contributor.googleauthor | 배성창 | - |
dc.contributor.googleauthor | 김혜원 | - |
dc.contributor.googleauthor | 김혜경 | - |
dc.contributor.googleauthor | 나은주 | - |
dc.contributor.googleauthor | 안보숙 | - |
dc.contributor.googleauthor | 최준용 | - |
dc.contributor.googleauthor | 김창오 | - |
dc.contributor.googleauthor | 김준명 | - |
dc.contributor.googleauthor | 송영구 | - |
dc.identifier.doi | 10.3947/ic.2009.41.4.224 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00953 | - |
dc.contributor.localId | A01044 | - |
dc.contributor.localId | A02037 | - |
dc.contributor.localId | A03983 | - |
dc.contributor.localId | A04191 | - |
dc.relation.journalcode | J01054 | - |
dc.subject.keyword | Vancomycin | - |
dc.subject.keyword | Therapeutic drug monitoring | - |
dc.subject.keyword | Cystatin C | - |
dc.contributor.alternativeName | Kim, June Myung | - |
dc.contributor.alternativeName | Kim, Chang Oh | - |
dc.contributor.alternativeName | Song, Young Goo | - |
dc.contributor.alternativeName | Jin, Sung Joon | - |
dc.contributor.alternativeName | Choi, Jun Yong | - |
dc.contributor.affiliatedAuthor | Kim, June Myung | - |
dc.contributor.affiliatedAuthor | Kim, Chang Oh | - |
dc.contributor.affiliatedAuthor | Song, Young Goo | - |
dc.contributor.affiliatedAuthor | Jin, Sung Joon | - |
dc.contributor.affiliatedAuthor | Choi, Jun Yong | - |
dc.citation.volume | 41 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 224 | - |
dc.citation.endPage | 229 | - |
dc.identifier.bibliographicCitation | INFECTION AND CHEMOTHERAPY (감염과 화학요법), Vol.41(4) : 224-229, 2009 | - |
dc.identifier.rimsid | 53747 | - |
dc.type.rims | ART | - |
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