Cited 5 times in
Prevalence of and clinical factors associated with lipoatrophy in HIV-infected Koreans receiving highly active antiretroviral therapy
DC Field | Value | Language |
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dc.contributor.author | 최준용 | - |
dc.contributor.author | 최희경 | - |
dc.contributor.author | 한상훈 | - |
dc.contributor.author | 김준명 | - |
dc.contributor.author | 김창오 | - |
dc.contributor.author | 백지현 | - |
dc.contributor.author | 송영구 | - |
dc.contributor.author | 신소연 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 진범식 | - |
dc.contributor.author | 채윤태 | - |
dc.date.accessioned | 2015-04-24T16:54:45Z | - |
dc.date.available | 2015-04-24T16:54:45Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0040-8727 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104406 | - |
dc.description.abstract | Lipoatrophy is the long-term adverse effects developed in human immunodeficiency virus (HIV)-1-infected subjects receiving highly active antiretroviral therapy (HAART). This cross-sectional study aimed to evaluate the prevalence of and clinical factors associated with lipoatrophy in HIV-infected Koreans receiving HAART for more than 6 months. Lipoatrophy was diagnosed by concordance between physical examination and history taking performed by a single physician. Various covariates were examined, including diabetes mellitus (DM), lipid profiles after HAART, and HAART regimen and duration. Among total 144 patients (6 females and 138 males), 35 patients (24.3%) were diagnosed with lipoatrophy. The prevalence of lipoatrophy was significantly higher in females than that in males [83.3% (5/6) vs. 21.7% (30/138), p = 0.010] and higher in patients with DM than patients without DM [66.7% (4/6 DM) vs. 22.5% (31/138 non-DM), p = 0.030], or in patients with high total cholesterol levels than patients with low total cholesterol levels [31.9% (23/72 patients with high cholesterol) vs. 16.7% (12/72 patients with low cholesterol), p = 0.035]. Moreover, patients with stavudine treatment history (> 12 months) had a higher prevalence of lipoatrophy than patients who never received stavudine [50.0% (15/30) vs. 16.5% (17/103), p < 0.001]. In the multivariate logistic analysis, stavudine treatment for > 12 months (OR, 3.67; p = 0.011) and being female (OR, 24.93; p = 0.009) are independently associated with lipoatrophy. In conclusion, the prevalence of lipoatrophy in HIV-infected Koreans receiving HAART is not uncommon. Limited use of stavudine and regular monitoring are warranted to reduce lipoatrophy | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 145~153 | - |
dc.relation.isPartOf | TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antiretroviral Therapy, Highly Active/adverse effects* | - |
dc.subject.MESH | Asian Continental Ancestry Group | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | HIV Infections/complications* | - |
dc.subject.MESH | HIV Infections/drug therapy* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lipodystrophy/chemically induced* | - |
dc.subject.MESH | Lipodystrophy/complications | - |
dc.subject.MESH | Lipodystrophy/diagnosis | - |
dc.subject.MESH | Lipodystrophy/epidemiology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Regression Analysis | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.title | Prevalence of and clinical factors associated with lipoatrophy in HIV-infected Koreans receiving highly active antiretroviral therapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Sang Hoon Han | - |
dc.contributor.googleauthor | Bum Sik Chin | - |
dc.contributor.googleauthor | Hee Kyoung Choi | - |
dc.contributor.googleauthor | So Youn Shin | - |
dc.contributor.googleauthor | Yun Tae Chae | - |
dc.contributor.googleauthor | Ji-Hyeon Baek | - |
dc.contributor.googleauthor | Chang Oh Kim | - |
dc.contributor.googleauthor | Jun Yong Choi | - |
dc.contributor.googleauthor | Young Goo Song | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.contributor.googleauthor | June Myung Kim | - |
dc.identifier.doi | 10.1620/tjem.219.145 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04191 | - |
dc.contributor.localId | A04228 | - |
dc.contributor.localId | A04286 | - |
dc.contributor.localId | A00953 | - |
dc.contributor.localId | A01044 | - |
dc.contributor.localId | A01839 | - |
dc.contributor.localId | A02037 | - |
dc.contributor.localId | A02116 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03981 | - |
dc.contributor.localId | A04022 | - |
dc.relation.journalcode | J02738 | - |
dc.identifier.eissn | 1349-3329 | - |
dc.identifier.pmid | 19776532 | - |
dc.subject.keyword | Lipoatrophy | - |
dc.subject.keyword | HIV | - |
dc.subject.keyword | Highly active antiretroviral therapy | - |
dc.subject.keyword | Stavudine | - |
dc.subject.keyword | Korea | - |
dc.contributor.alternativeName | Choi, Jun Yong | - |
dc.contributor.alternativeName | Choi, Hee Kyoung | - |
dc.contributor.alternativeName | Han, Sang Hoon | - |
dc.contributor.alternativeName | Kim, June Myung | - |
dc.contributor.alternativeName | Kim, Chang Oh | - |
dc.contributor.alternativeName | Baek, Ji Hyeon | - |
dc.contributor.alternativeName | Song, Young Goo | - |
dc.contributor.alternativeName | Shin, So Youn | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Chin, Bum Sik | - |
dc.contributor.alternativeName | Chae, Yun Tae | - |
dc.contributor.affiliatedAuthor | Choi, Jun Yong | - |
dc.contributor.affiliatedAuthor | Choi, Hee Kyoung | - |
dc.contributor.affiliatedAuthor | Han, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Kim, June Myung | - |
dc.contributor.affiliatedAuthor | Kim, Chang Oh | - |
dc.contributor.affiliatedAuthor | Baek, Ji Hyeon | - |
dc.contributor.affiliatedAuthor | Song, Young Goo | - |
dc.contributor.affiliatedAuthor | Shin, So Youn | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Chin, Bum Sik | - |
dc.contributor.affiliatedAuthor | Chae, Yun Tae | - |
dc.citation.volume | 219 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 145 | - |
dc.citation.endPage | 153 | - |
dc.identifier.bibliographicCitation | TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, Vol.219(2) : 145-153, 2009 | - |
dc.identifier.rimsid | 53742 | - |
dc.type.rims | ART | - |
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