Cited 37 times in
The predictive role of E-cadherin and androgen receptor on in vitro chemosensitivity in triple-negative breast Cancer.
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 정우희 | - |
dc.contributor.author | 정준 | - |
dc.date.accessioned | 2015-04-24T16:53:08Z | - |
dc.date.available | 2015-04-24T16:53:08Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0368-2811 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104357 | - |
dc.description.abstract | OBJECTIVE: The purpose of this study was to evaluate the impact of various pathologic and biologic factors in triple-negative breast cancer (TNBC) on chemotherapy response using in vitro ATP-based chemotherapy response assay (ATP-CRA). METHODS: Forty-seven cases of TNBC were included. Immunohistochemical stains for androgen receptor (AR), p53, CD10, c-kit, CK5/6, vimentin, bcl-2, E-cadherin, Ki-67 and epidermal growth factor receptor were performed. In vitro ATP-CRA was used to analyze chemosensitivity for 5-fluorouracil (5-FU), docetaxel, doxorubicin, epirubicin, vinorelbine, gemcitabine, methotrexate (MTX), oxaliplatin and paclitaxel. RESULTS: The results showed that all cytotoxic agents demonstrated the trend that E-cadherin-expressing cases had a higher cell death rate than E-cadherin-negative cases. Particularly, vinorelbine showed statistical significance (P = 0.004). Cases with AR expression showed higher cell death rates than those without in 5-FU and MTX (P = 0.012 and 0.014, respectively). CONCLUSIONS: E-cadherin and AR could be candidate predictive factors for chemotherapy response in TNBC. Further in vivo study is required to clarify their roles. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 560~568 | - |
dc.relation.isPartOf | JAPANESE JOURNAL OF CLINICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/drug therapy | - |
dc.subject.MESH | Adenocarcinoma/metabolism | - |
dc.subject.MESH | Adenocarcinoma/mortality | - |
dc.subject.MESH | Adenosine Triphosphate/metabolism | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antineoplastic Agents/therapeutic use* | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/drug therapy* | - |
dc.subject.MESH | Breast Neoplasms/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/mortality | - |
dc.subject.MESH | Cadherins/metabolism* | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/drug therapy | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/metabolism | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/mortality | - |
dc.subject.MESH | Carcinoma, Medullary/drug therapy | - |
dc.subject.MESH | Carcinoma, Medullary/metabolism | - |
dc.subject.MESH | Carcinoma, Medullary/mortality | - |
dc.subject.MESH | Cell Death/drug effects | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ki-67 Antigen/metabolism | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Proto-Oncogene Proteins c-bcl-2/metabolism | - |
dc.subject.MESH | Receptors, Androgen/metabolism* | - |
dc.subject.MESH | Tumor Suppressor Protein p53/metabolism | - |
dc.title | The predictive role of E-cadherin and androgen receptor on in vitro chemosensitivity in triple-negative breast Cancer. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.contributor.googleauthor | Woohee Jung | - |
dc.contributor.googleauthor | Joon Jeong | - |
dc.identifier.doi | 10.1093/jjco/hyp065 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A03671 | - |
dc.contributor.localId | A03727 | - |
dc.relation.journalcode | J01207 | - |
dc.identifier.eissn | 1465-3621 | - |
dc.identifier.pmid | 19531543 | - |
dc.subject.keyword | androgen receptor | - |
dc.subject.keyword | breast cancer | - |
dc.subject.keyword | chemosensitivity | - |
dc.subject.keyword | E-cadherin | - |
dc.subject.keyword | triple negative | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.alternativeName | Jeong, Joon | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Jeong, Joon | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 39 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 560 | - |
dc.citation.endPage | 568 | - |
dc.identifier.bibliographicCitation | JAPANESE JOURNAL OF CLINICAL ONCOLOGY, Vol.39(9) : 560-568, 2009 | - |
dc.identifier.rimsid | 52616 | - |
dc.type.rims | ART | - |
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