시멘트 보강술을 시행한 골다공증성 척추 골절 환자에서 리세드로네이트, 알렌드로네이트와 칼슘 카보네이트 약물치료 후 발생하는 척추 골절의 비교 연구

Abstract

Purpose: To evaluate the rate of new fractures of the spine after risedronate, alendronate or calcium carbonate in patients who had vertebroplasty or kyphoplasty due to compression fracture. Materials and Methods: We studied 292 patients with osteoporotic compression fractures who had received vertebroplasty or kyophoplasty between June 2003 and October 2007. Of these, 199 were evaluated for new fractures of the spine after treatment with risedronate, alendronate or calcium carbonate. Patients (n=199) were assigned to 1 of 4 groups: No treatment (n=71), risendronate (n=64), alendronate (n=42) or calcium carbonate group (n=22). Results: New fractures of the spine were morphogenically found in 19 patients (26.8%) in the no treatment group, in 11 (17.2%) in the risendronate group, in 8 (19.1 %) in the alendronate group, in 5 (22.8%) in the calcium carbonate group. Symptomatically, they were found in 6 patients (8.5%) in the no treatment group, in 4 (6.3%) in the risendronate group, in 3 patients (7.1 %) in the alendronate group, and in 2 patients (9.1 %) in the calcium carbonate group. Conclusion: At one year follow up none of the differences between groups in new fracture rates of the spine were statistically significant.