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결장암에서 5-Fluorouracil-based 보조항암화학요법의 치료반응 예측인자로써 점액성 선암의 의의

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dc.contributor.author손승국-
dc.contributor.author이강영-
dc.contributor.author조장환-
dc.contributor.author강정현-
dc.contributor.author김남규-
dc.contributor.author민병소-
dc.contributor.author박윤아-
dc.date.accessioned2015-04-24T16:52:29Z-
dc.date.available2015-04-24T16:52:29Z-
dc.date.issued2009-
dc.identifier.issn2287-9714-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104337-
dc.description.abstractPurpose: The aim of this study was to evaluate the value of mucinous histology as a predictive marker of 5-Fluorouracil (FU)-based adjuvant chemotherapy in stage II, III colon cancer. Methods: Between January 1995 and December 2004, 987 patients who underwent curative resections for stage II, III sporadic colon cancer were classified into two groups, a mucinous carcinoma (MC) group and a non-mucinous carcinoma (NMC) group, based on the histology of the primary tumor. The differences in their clinicopathological characteristics and the prognostic impact of 5-FU-based adjuvant chemotherapy for various tumor histologies were analyzed. Results: Of the 987 patients, MCs accounted for 6.8% (68 patients). MCs were more frequently located in the Rt. Colon (P<0.001) and were more frequently seen in young patients (less than 40 yr old) (P=0.028). The 5-yr survival rates between MC and NMC did not show any statistically significant difference. Patients, including both MC and NMC patients, who received 5-FU-based chemotherapy, revealed a better overall survival rate than patients with no adjuvant chemotherapy. In the multivariate analysis for the prognosis in NMC patients, 5-FU-based adjuvant chemotherapy, initial negative nodal status, and preoperative CEA <5 ng/mL were statistically significant prognostic factors (P values: <0.001, <0.001, and <0.001, respectively). In contrast, there was no statistically independent significance of 5-FU-based adjuvant chemotherapy in MC patients. Conslusion: In stage II and stage III sporadic colon cancer patients, response to 5-FU-based adjuvant chemotherapy in MC patients might be poor than it is in NMC patients-
dc.description.statementOfResponsibilityopen-
dc.format.extent241~247-
dc.languageKorean-
dc.publisher대한대장항문학회-
dc.relation.isPartOfJournal of the Korean Society of Coloproctology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title결장암에서 5-Fluorouracil-based 보조항암화학요법의 치료반응 예측인자로써 점액성 선암의 의의-
dc.title.alternativeMucinous Histology as a Predictive Marker of 5-Fluorouracil-based Adjuvant Chemotherapy for Colon Cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthor강정현-
dc.contributor.googleauthor민병소-
dc.contributor.googleauthor박윤아-
dc.contributor.googleauthor김남규-
dc.contributor.googleauthor손승국-
dc.contributor.googleauthor조장환-
dc.contributor.googleauthor이강영-
dc.identifier.doi10.3393/jksc.2009.25.4.241-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01978-
dc.contributor.localIdA02640-
dc.contributor.localIdA03894-
dc.contributor.localIdA00080-
dc.contributor.localIdA00353-
dc.contributor.localIdA01402-
dc.contributor.localIdA01599-
dc.relation.journalcodeJ01864-
dc.identifier.eissn2287-9722-
dc.subject.keywordMucinous carcinoma-
dc.subject.keywordAdjuvant chemotherapy-
dc.subject.keywordColon cancer-
dc.contributor.alternativeNameSohn, Seung Kook-
dc.contributor.alternativeNameLee, Kang Young-
dc.contributor.alternativeNameCho, Chang Hwan-
dc.contributor.alternativeNameKang, Jeong Hyun-
dc.contributor.alternativeNameKim, Nam Kyu-
dc.contributor.alternativeNameMin, Byung Soh-
dc.contributor.alternativeNamePark, Yoon Ah-
dc.contributor.affiliatedAuthorSohn, Seung Kook-
dc.contributor.affiliatedAuthorLee, Kang Young-
dc.contributor.affiliatedAuthorCho, Chang Hwan-
dc.contributor.affiliatedAuthorKang, Jeong Hyun-
dc.contributor.affiliatedAuthorKim, Nam Kyu-
dc.contributor.affiliatedAuthorMin, Byung Soh-
dc.contributor.affiliatedAuthorPark, Yoon Ah-
dc.citation.volume25-
dc.citation.number4-
dc.citation.startPage241-
dc.citation.endPage247-
dc.identifier.bibliographicCitationJournal of the Korean Society of Coloproctology, Vol.25(4) : 241-247, 2009-
dc.identifier.rimsid52603-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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