Cited 16 times in
[6]-Gingerol suppresses interleukin-1 beta-induced MUC5AC gene expression in human airway epithelial cells.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권순호 | - |
dc.contributor.author | 김경수 | - |
dc.contributor.author | 윤주헌 | - |
dc.date.accessioned | 2015-04-24T16:47:12Z | - |
dc.date.available | 2015-04-24T16:47:12Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1945-8924 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104168 | - |
dc.description.abstract | BACKGROUND: [6]-Gingerol is a major active component of ginger and a natural polyphenol compound. The present study investigated whether [6]-gingerol suppresses interleukin (IL)-1 beta-induced MUC5AC gene expression in human airway epithelial cells and, if so, examined whether the suppression of MUC5AC gene expression is mediated via the mitogen-activated protein kinase (MAPK) signal transduction pathway. METHODS: MUC5AC mRNA and protein were measured using reverse transcription-polymerase chain reaction (PCR), real-time PCR, and Western blot analysis in cultured NCI-H292 human airway epithelial cells. Extracellular signal-regulated kinase (ERK) and p38 MAPK protein levels were analyzed by Western blot. RESULTS: Expression of MUC5AC mRNA increased in NCI-H292 cells upon treatment with 10 ng/mL of IL-1 beta for 24 hours. When the cells were pretreated with 10 microM of [6]-gingerol, expression of IL-1 beta-induced MUC5AC mRNA and protein was significantly suppressed. Suppression of IL-1 beta-induced MUC5AC mRNA was also observed in cells pretreated with ERK- or p38 MAPK-specific inhibitors, suggesting that [6]-gingerol-mediated suppression of IL-1 beta-induced MUC5AC mRNA operated via the ERK- and p38 MAPK-dependent pathways. CONCLUSIONS: [6]-Gingerol suppresses IL-1 beta -induced MUC5AC gene expression in human airway epithelial cells via the ERK- and p38 MAPK-dependent pathways; therefore, [6]-gingerol may be considered a possible anti-hypersecretory agent. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 385~391 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF RHINOLOGY & ALLERGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Catechols/pharmacology* | - |
dc.subject.MESH | Cell Proliferation/drug effects | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Extracellular Signal-Regulated MAP Kinases/pharmacology | - |
dc.subject.MESH | Fatty Alcohols/pharmacology* | - |
dc.subject.MESH | Gene Expression Regulation/drug effects* | - |
dc.subject.MESH | Ginger | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-1beta/pharmacology* | - |
dc.subject.MESH | Mucin 5AC/biosynthesis | - |
dc.subject.MESH | Mucin 5AC/drug effects | - |
dc.subject.MESH | Mucin 5AC/genetics* | - |
dc.subject.MESH | RNA, Messenger/biosynthesis | - |
dc.subject.MESH | RNA, Messenger/drug effects | - |
dc.subject.MESH | RNA, Messenger/genetics* | - |
dc.subject.MESH | Respiratory Mucosa/cytology | - |
dc.subject.MESH | Respiratory Mucosa/drug effects | - |
dc.subject.MESH | Respiratory Mucosa/metabolism* | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Signal Transduction/drug effects | - |
dc.subject.MESH | p38 Mitogen-Activated Protein Kinases/pharmacology | - |
dc.title | [6]-Gingerol suppresses interleukin-1 beta-induced MUC5AC gene expression in human airway epithelial cells. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학) | - |
dc.contributor.googleauthor | Jeong Hong Kim | - |
dc.contributor.googleauthor | Jung Hyun Chang | - |
dc.contributor.googleauthor | Joo-Heon Yoon | - |
dc.contributor.googleauthor | Soon Ho Kwon | - |
dc.contributor.googleauthor | Jung Ho Bae | - |
dc.contributor.googleauthor | Kyung-Su Kim | - |
dc.identifier.doi | 10.2500/ajra.2009.23.3337 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00223 | - |
dc.contributor.localId | A00298 | - |
dc.contributor.localId | A02604 | - |
dc.relation.journalcode | J00115 | - |
dc.identifier.eissn | 1945-8932 | - |
dc.identifier.pmid | 19671252 | - |
dc.identifier.url | http://www.ingentaconnect.com/content/ocean/ajra/2009/00000023/00000004/art00004?token=004e15f7536a141333c4a2f7a7a6a6f572b6756767034254f6d622244502c6876305021180142c | - |
dc.subject.keyword | Antihypersecretory agent | - |
dc.subject.keyword | extracellular signal-regulated kinase | - |
dc.subject.keyword | [6]-gingerol | - |
dc.subject.keyword | human airway epithelial cell | - |
dc.subject.keyword | inter-leukin-1 beta | - |
dc.subject.keyword | p38 mitogen-activated protein kinase | - |
dc.subject.keyword | MUC5AC | - |
dc.contributor.alternativeName | Kwon, Soon Ho | - |
dc.contributor.alternativeName | Kim, Kyung Su | - |
dc.contributor.alternativeName | Yoon, Joo Heon | - |
dc.contributor.affiliatedAuthor | Kwon, Soon Ho | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Su | - |
dc.contributor.affiliatedAuthor | Yoon, Joo Heon | - |
dc.citation.volume | 23 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 385 | - |
dc.citation.endPage | 391 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, Vol.23(4) : 385-391, 2009 | - |
dc.identifier.rimsid | 54587 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.