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[6]-Gingerol suppresses interleukin-1 beta-induced MUC5AC gene expression in human airway epithelial cells.

DC Field Value Language
dc.contributor.author권순호-
dc.contributor.author김경수-
dc.contributor.author윤주헌-
dc.date.accessioned2015-04-24T16:47:12Z-
dc.date.available2015-04-24T16:47:12Z-
dc.date.issued2009-
dc.identifier.issn1945-8924-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104168-
dc.description.abstractBACKGROUND: [6]-Gingerol is a major active component of ginger and a natural polyphenol compound. The present study investigated whether [6]-gingerol suppresses interleukin (IL)-1 beta-induced MUC5AC gene expression in human airway epithelial cells and, if so, examined whether the suppression of MUC5AC gene expression is mediated via the mitogen-activated protein kinase (MAPK) signal transduction pathway. METHODS: MUC5AC mRNA and protein were measured using reverse transcription-polymerase chain reaction (PCR), real-time PCR, and Western blot analysis in cultured NCI-H292 human airway epithelial cells. Extracellular signal-regulated kinase (ERK) and p38 MAPK protein levels were analyzed by Western blot. RESULTS: Expression of MUC5AC mRNA increased in NCI-H292 cells upon treatment with 10 ng/mL of IL-1 beta for 24 hours. When the cells were pretreated with 10 microM of [6]-gingerol, expression of IL-1 beta-induced MUC5AC mRNA and protein was significantly suppressed. Suppression of IL-1 beta-induced MUC5AC mRNA was also observed in cells pretreated with ERK- or p38 MAPK-specific inhibitors, suggesting that [6]-gingerol-mediated suppression of IL-1 beta-induced MUC5AC mRNA operated via the ERK- and p38 MAPK-dependent pathways. CONCLUSIONS: [6]-Gingerol suppresses IL-1 beta -induced MUC5AC gene expression in human airway epithelial cells via the ERK- and p38 MAPK-dependent pathways; therefore, [6]-gingerol may be considered a possible anti-hypersecretory agent.-
dc.description.statementOfResponsibilityopen-
dc.format.extent385~391-
dc.relation.isPartOfAMERICAN JOURNAL OF RHINOLOGY & ALLERGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBlotting, Western-
dc.subject.MESHCatechols/pharmacology*-
dc.subject.MESHCell Proliferation/drug effects-
dc.subject.MESHCells, Cultured-
dc.subject.MESHExtracellular Signal-Regulated MAP Kinases/pharmacology-
dc.subject.MESHFatty Alcohols/pharmacology*-
dc.subject.MESHGene Expression Regulation/drug effects*-
dc.subject.MESHGinger-
dc.subject.MESHHumans-
dc.subject.MESHInterleukin-1beta/pharmacology*-
dc.subject.MESHMucin 5AC/biosynthesis-
dc.subject.MESHMucin 5AC/drug effects-
dc.subject.MESHMucin 5AC/genetics*-
dc.subject.MESHRNA, Messenger/biosynthesis-
dc.subject.MESHRNA, Messenger/drug effects-
dc.subject.MESHRNA, Messenger/genetics*-
dc.subject.MESHRespiratory Mucosa/cytology-
dc.subject.MESHRespiratory Mucosa/drug effects-
dc.subject.MESHRespiratory Mucosa/metabolism*-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHSignal Transduction/drug effects-
dc.subject.MESHp38 Mitogen-Activated Protein Kinases/pharmacology-
dc.title[6]-Gingerol suppresses interleukin-1 beta-induced MUC5AC gene expression in human airway epithelial cells.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학)-
dc.contributor.googleauthorJeong Hong Kim-
dc.contributor.googleauthorJung Hyun Chang-
dc.contributor.googleauthorJoo-Heon Yoon-
dc.contributor.googleauthorSoon Ho Kwon-
dc.contributor.googleauthorJung Ho Bae-
dc.contributor.googleauthorKyung-Su Kim-
dc.identifier.doi10.2500/ajra.2009.23.3337-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00223-
dc.contributor.localIdA00298-
dc.contributor.localIdA02604-
dc.relation.journalcodeJ00115-
dc.identifier.eissn1945-8932-
dc.identifier.pmid19671252-
dc.identifier.urlhttp://www.ingentaconnect.com/content/ocean/ajra/2009/00000023/00000004/art00004?token=004e15f7536a141333c4a2f7a7a6a6f572b6756767034254f6d622244502c6876305021180142c-
dc.subject.keywordAntihypersecretory agent-
dc.subject.keywordextracellular signal-regulated kinase-
dc.subject.keyword[6]-gingerol-
dc.subject.keywordhuman airway epithelial cell-
dc.subject.keywordinter-leukin-1 beta-
dc.subject.keywordp38 mitogen-activated protein kinase-
dc.subject.keywordMUC5AC-
dc.contributor.alternativeNameKwon, Soon Ho-
dc.contributor.alternativeNameKim, Kyung Su-
dc.contributor.alternativeNameYoon, Joo Heon-
dc.contributor.affiliatedAuthorKwon, Soon Ho-
dc.contributor.affiliatedAuthorKim, Kyung Su-
dc.contributor.affiliatedAuthorYoon, Joo Heon-
dc.citation.volume23-
dc.citation.number4-
dc.citation.startPage385-
dc.citation.endPage391-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF RHINOLOGY & ALLERGY, Vol.23(4) : 385-391, 2009-
dc.identifier.rimsid54587-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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