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Treatment and outcomes of primary intracranial teratoma

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dc.contributor.author김동석-
dc.contributor.author박영석-
dc.contributor.author박은경-
dc.contributor.author심규원-
dc.contributor.author이윤호-
dc.contributor.author최중언-
dc.date.accessioned2015-04-24T16:46:45Z-
dc.date.available2015-04-24T16:46:45Z-
dc.date.issued2009-
dc.identifier.issn0256-7040-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104154-
dc.description.abstractPURPOSE: Until recently, postoperative adjuvant treatment for intracranial teratomas has remained controversial because of the rarity of the tumors and the heterogeneity of histologic types. To define optimal therapy modalities, we retrospectively analyzed the treatment of patients with intracranial teratomas. METHODS: Between 1979 and 2007, 31 patients with intracranial teratomas were treated at our institution. The median age of the 31 patients was 14.8 years. The median follow-up time was 72.7 months (range 11 approximately 291 months). Perioperative radiochemotherapy was done in 19 patients. Proper chemotherapy regimens were followed, such as PE (cisplatin and VP-16), PVB (cisplatin, VP-16, and bleomycin), ICE (carboplatin, VP-16, and ifosfamide), and NGGCT (etoposide, carboplatin, bleomycin, and cyclophosphamide with mesna). RESULTS: Eight patients experienced recurrence, and a second operation was carried out in six patients. Fifteen patients survived for more than 5 years without recurrence, irrespective of having received adjuvant therapies. The 5-year survival rate of the 31 patients was 74%. CONCLUSION: Treatment of intracranial teratomas is very difficult because of the heterogeneity of the tumor cells from totipotent origins. Accurate histological diagnosis of teratoma subtypes is the most important factor for adequate treatment, and proper therapeutic protocols are needed to cure teratomas.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1581~1587-
dc.relation.isPartOfCHILDS NERVOUS SYSTEM-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHBrain Neoplasms/diagnosis-
dc.subject.MESHBrain Neoplasms/therapy*-
dc.subject.MESHChemotherapy, Adjuvant-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHDrug Administration Schedule-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Recurrence, Local-
dc.subject.MESHPrognosis-
dc.subject.MESHTeratoma/diagnosis-
dc.subject.MESHTeratoma/therapy*-
dc.subject.MESHTreatment Outcome-
dc.titleTreatment and outcomes of primary intracranial teratoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학)-
dc.contributor.googleauthorYun-Ho Lee-
dc.contributor.googleauthorEun Kyung Park-
dc.contributor.googleauthorYoung Seok Park-
dc.contributor.googleauthorKyu-Won Shim-
dc.contributor.googleauthorJoong-Uhn Choi-
dc.contributor.googleauthorDong-Seok Kim-
dc.identifier.doi10.1007/s00381-009-0974-8-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00402-
dc.contributor.localIdA01568-
dc.contributor.localIdA01607-
dc.contributor.localIdA02187-
dc.contributor.localIdA03030-
dc.contributor.localIdA04194-
dc.relation.journalcodeJ00525-
dc.identifier.eissn1433-0350-
dc.identifier.pmid19693515-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00381-009-0974-8-
dc.subject.keywordAdjuvant therapy-
dc.subject.keywordChemotherapy-
dc.subject.keywordIntracranial-
dc.subject.keywordRadiation therapy-
dc.subject.keywordTeratoma-
dc.contributor.alternativeNameKim, Dong Seok-
dc.contributor.alternativeNamePark, Young Seok-
dc.contributor.alternativeNamePark, Eun Kyung-
dc.contributor.alternativeNameShim, Kyu Won-
dc.contributor.alternativeNameLee, Yun Ho-
dc.contributor.alternativeNameChoi, Joong Uhn-
dc.contributor.affiliatedAuthorKim, Dong Seok-
dc.contributor.affiliatedAuthorPark, Young Seok-
dc.contributor.affiliatedAuthorPark, Eun Kyung-
dc.contributor.affiliatedAuthorShim, Kyu Won-
dc.contributor.affiliatedAuthorLee, Yun Ho-
dc.contributor.affiliatedAuthorChoi, Joong Uhn-
dc.citation.volume25-
dc.citation.number12-
dc.citation.startPage1581-
dc.citation.endPage1587-
dc.identifier.bibliographicCitationCHILDS NERVOUS SYSTEM, Vol.25(12) : 1581-1587, 2009-
dc.identifier.rimsid54578-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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