Cited 10 times in
Glassy cell carcinoma predominantly commits to a squamous lineage and is strongly associated with high-risk type human papillomavirus infection.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 심효섭 | - |
dc.contributor.author | 이광길 | - |
dc.contributor.author | 조남훈 | - |
dc.date.accessioned | 2015-04-24T16:46:43Z | - |
dc.date.available | 2015-04-24T16:46:43Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0277-1691 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104153 | - |
dc.description.abstract | SUMMARY: Glassy cell carcinoma (GCC) has been believed to have originated from reserve or uncommitted cells as a poorly differentiated adenosquamous carcinoma. This study includes immunoprofiles of p63, cytokeratin 17 (CK17), and CD44 to clarify which lineage of GCC is committed to human papillomavirus (HPV) detection, and to verify whether or not HPV plays a role in GCC. Nine uterine GCCs showing overwhelmingly glassy features were evaluated by an HPV genotyping chip and by immunohistochemistry for E-cadherin, CD44, p63, CEA, erb-B2, cytokeratin 17, and p16. An HPV genotyping DNA chip array with multiple oligonucleotide probes of L1 sequences from 26 types of HPV was introduced. GCCs were variably stained, except for CD44 which was stained unanimously. A lack of E-cadherin was found in 4 cases, frequent expression of p63 in 6/9 (66.7%), mucin stain or CEA in 5/9 (55.6%), and coexpression of p63 in 4. HPV prevalence in GCC was found in 6/9 cases (66.7%). HPV-18 and HPV-32 were the most common types detected. The remaining cancers were infected by HPV-31, HPV-35, HPV-39, and HPV-68. Multiple infections were found in 2 out of 6 cases. GCC could not be precisely categorized, but was committed to squamous lineages and was strongly associated with high-risk type HPV infection. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 389~395 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Biomarkers, Tumor/analysis | - |
dc.subject.MESH | Carcinoma, Adenosquamous/metabolism | - |
dc.subject.MESH | Carcinoma, Adenosquamous/pathology | - |
dc.subject.MESH | Carcinoma, Adenosquamous/virology* | - |
dc.subject.MESH | Cell Lineage | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis | - |
dc.subject.MESH | Papillomavirus Infections/complications* | - |
dc.subject.MESH | Papillomavirus Infections/genetics | - |
dc.subject.MESH | Papillomavirus Infections/pathology | - |
dc.subject.MESH | Polymorphism, Restriction Fragment Length | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Uterine Neoplasms/metabolism | - |
dc.subject.MESH | Uterine Neoplasms/pathology* | - |
dc.subject.MESH | Uterine Neoplasms/virology* | - |
dc.title | Glassy cell carcinoma predominantly commits to a squamous lineage and is strongly associated with high-risk type human papillomavirus infection. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Sang-Kyum Kim | - |
dc.contributor.googleauthor | Hyo-Sup Shim | - |
dc.contributor.googleauthor | Kwang-Gil Lee | - |
dc.contributor.googleauthor | Hee-Jung An | - |
dc.contributor.googleauthor | Kyung-Rhul Lee | - |
dc.contributor.googleauthor | Nam-Hoon Cho | - |
dc.identifier.doi | 10.1097/PGP.0b013e31819343a5 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02219 | - |
dc.contributor.localId | A02667 | - |
dc.contributor.localId | A03812 | - |
dc.relation.journalcode | J01116 | - |
dc.identifier.eissn | 1538-7151 | - |
dc.identifier.pmid | 19483622 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00004347-200907000-00016&LSLINK=80&D=ovft | - |
dc.subject.keyword | Glassy cell carcinoma | - |
dc.subject.keyword | Human papillomavirus | - |
dc.subject.keyword | p63 | - |
dc.contributor.alternativeName | Shim, Hyo Sup | - |
dc.contributor.alternativeName | Lee, Kwang Gill | - |
dc.contributor.alternativeName | Cho, Nam Hoon | - |
dc.contributor.affiliatedAuthor | Shim, Hyo Sup | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Gill | - |
dc.contributor.affiliatedAuthor | Cho, Nam Hoon | - |
dc.citation.volume | 28 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 389 | - |
dc.citation.endPage | 395 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, Vol.28(4) : 389-395, 2009 | - |
dc.identifier.rimsid | 54577 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.