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Usefulness of FibroScan for detection of early compensated liver cirrhosis in chronic hepatitis B

 Do Young Kim  ;  Seung Up Kim  ;  Sang Hoon Ahn  ;  Jun Yong Park  ;  Jung Min Lee  ;  Young Nyun Park  ;  Ki Tae Yoon  ;  Yong Han Paik  ;  Kwan Sik Lee  ;  Chae Yoon Chon  ;  Kwang-Hyub Han 
 DIGESTIVE DISEASES AND SCIENCES, Vol.54(8) : 1758-1763, 2009 
Journal Title
Issue Date
Adult ; Biopsy ; Diagnosis, Differential ; Elasticity Imaging Techniques/methods* ; Female ; Hepatitis B, Chronic/diagnostic imaging* ; Humans ; Liver/diagnostic imaging ; Liver/pathology ; Liver Cirrhosis/diagnostic imaging* ; Male ; Middle Aged ; Predictive Value of Tests ; ROC Curve ; Sensitivity and Specificity
Liver stiffness measurement ; Chronic hepatitis B ; Compensated liver cirrhosis
BACKGROUND: It is difficult to differentiate early compensated cirrhosis from chronic hepatitis solely by clinical features. The aim of this study was to assess the usefulness of liver stiffness measurement (LSM) for detection of early compensated liver cirrhosis in chronic hepatitis B (CHB). METHODS: Ninety-one consecutive CHB patients who underwent liver biopsy (LB) and LSM were recruited. All patients did not fulfill the clinical criteria for cirrhosis. The cutoff of LSM for cirrhosis was 10.3 kPa. RESULTS: All patients were divided into either group A (cirrhosis) or group B (CHB) according to LB result. The median LSM values of groups A and B were 11.8 and 7.6 kPa, respectively (P < 0.001). The sensitivity, specificity, positive predictive value, and negative predictive value of LSM in predicting cirrhosis were 0.59, 0.78, 0.68, and 0.72, respectively. The area under the receiver operating characteristics curve (AUROC) of LSM was 0.803, whereas the AUROCs of aspartate to alanine aminotransferase ratio (AAR) and aspartate aminotransferase to platelet ratio index (APRI) were 0.488 and 0.723, respectively. CONCLUSIONS: LSM showed an acceptable diagnostic accuracy for detecting early compensated cirrhosis in CHB.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Paik, Yong Han(백용한)
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Yoon, Ki Tae(윤기태)
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
Lee, Jung Min(이중민)
Chon, Chae Yoon(전재윤)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
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