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The behavioral change of locomotor activity in a kaolin-induced hydrocephalus rat model: evaluation of the effect on the dopaminergic system with progressive ventricle dilatation.

Authors
 Yong Sup Hwang  ;  Insop Shim  ;  JinWoo Chang 
Citation
 NEUROSCIENCE LETTERS, Vol.462(3) : 198-202, 2009 
Journal Title
NEUROSCIENCE LETTERS
ISSN
 0304-3940 
Issue Date
2009
MeSH
Animals ; Cerebral Ventricles/pathology* ; Dilatation, Pathologic ; Dopamine/physiology* ; Hydrocephalus/chemically induced ; Hydrocephalus/enzymology ; Hydrocephalus/psychology* ; Kaolin* ; Male ; Maze Learning ; Motor Activity* ; Neurons/enzymology ; Rats ; Rats, Sprague-Dawley ; Substantia Nigra/enzymology ; Tyrosine 3-Monooxygenase/metabolism
Keywords
Dopamine ; Kaolin ; Hydrocephalus ; Elevated plus maze ; Locomotor activity
Abstract
Hydrocephalus is a pathological enlargement of the cerebral ventricle that results from an obstruction of the space containing cerebrospinal fluid (CSF) in the brain. Motor abnormalities, such as abnormal gait and posture, are frequently seen in patients with hydrocephalus. The present study was designed to investigate locomotor activity in the elevated plus maze behaviorally. Hydrocephalus was induced in Sprague-Dawley rats by injection of 0.1 ml of 20% kaolin solution into the cisterna magna (n=14). Control rats received the same volume of saline (n=12). The rats were sacrificed at 3 days and 4 weeks after the elevated plus maze test. Tyrosine hydroxlyase (TH) immunoreactivity in the substantia nigra was evaluated by immunohistological staining. Hydrocephalic rats showed decreased motor activity for entries of arms when compared to control rats (p<0.05). Compared to control rats, the number of TH immunoreactive neurons was significantly decreased in hydrocephalic rats. These results suggest that decreased motor responses due to ventricle enlargement in hydrocephalic rats are associated with the functional impairment of the central dopamine system.
Full Text
http://www.sciencedirect.com/science/article/pii/S0304394009009501
DOI
10.1016/j.neulet.2009.07.039
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
Hwang, Yong Sup(황용섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104092
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