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최근 5년간 신증후군 출혈열의 임상양상 : 백신 도입 이전과 비교

Other Titles
 The influence of vaccination on the clinical features of hemorrhagic fever with renal syndrome in the last 5 years 
 이남석  ;  김효열  ;  채명훈  ;  김은미  ;  박소연  ;  한상훈  ;  권오건  ;  어 영 
 Korean Journal of Medicine, Vol.76(4) : 459-466, 2009 
Journal Title
Korean Journal of Medicine
Issue Date
Hemorrhagic Fever with Renal Syndrome ; Vaccination ; Hantaan virus
Background/Aims: Hemorrhagic fever with renal syndrome (HFRS) caused by Hantaan virus is an endemic febrile disease in Korea. Although inactivated Hantaan virus vaccine has been introduced, the effect of vaccination is not clear. We evaluated the effect of vaccination on the incidence rate and clinical features of HFRS based on our clinical experience.

Methods: Group I consisted of the patients with confirmed HFRS from a total of 131 patients who were seropositive for Hantaan virus at one tertiary teaching hospital from January 2002 to December 2006. Group II contained 100 patients treated as HFRS at the same hospital from January 1986 to December 1990, before the introduction of the vaccine. Then, we compared the clinical features of the two groups. We confirmed whether the patients had been vaccinated by reviewing their medical records and from telephone interviews.

Results: Only 16 (12.2%) of the 131 patients who were seropositive for Hantaan virus were confirmed to have overt HFRS during the most recent 5 years. The incidence of overt HFRS was significantly lower in vaccinees (5%, 3 of 56) than in non-vaccinees (20%, 10 of 50) (p=0.025). The prevalence of renal failure (62.5 vs. 95%, p<0.001) and oliguria (6.25 vs. 46%, p=0.002) was significantly lower in group I than in group II. Three patients were treated with dialysis and none died in group I, versus 17 and 8, respectively, in group II.

Conclusions: It appears that Hantaan virus vaccine has helped to reduce the amount of serious illness and the occurrence of HFRS.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
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