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Desflurane의 세로토닌3A형 수용체 항진작용에 대한 인삼사포닌의 효과
DC Field | Value | Language |
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dc.contributor.author | 구본녀 | - |
dc.contributor.author | 민경태 | - |
dc.contributor.author | 최승호 | - |
dc.date.accessioned | 2015-04-24T16:42:51Z | - |
dc.date.available | 2015-04-24T16:42:51Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 2005-6419 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104033 | - |
dc.description.abstract | BACKGROUND: Postoperative nausea and vomiting (PONV) is the most frequent and discomforting side effect following general anesthesia. Most volatile anesthetics have a potent effect on serotonin (5-hydroxydtryptamine, 5-HT) type 3 receptor mediating PONV, and their antagonists have been currently used effectively to prevent and/or reduce the incidence and severity of PONV. The authors reported previously that ginsenosides have inhibitory effect on 5-HT3A receptor. In this study we intended to elucidate the inhibitory effect of ginsenosides on the potentiated 5-HT3A receptor by desflurane. METHODS: After in vitro transcription of the recombinant mouse 5-HT3A receptor in the Xenopus laevis oocyte, we examined the effects of ginsenosides (g-Rb1, g-Rg1, g-Rd, g-Rg2) as well as ginsenoside metabolite, compound K on the modulation of desflurane by measuring currents flowing through 5-HT3A receptor using two-electrode voltage clamp technique. RESULTS: Although normalized inhibitory responses of ginsenosides were same regardless of desflurane, some ginsenosides such as g-Rd, g-Rg2, and g-Rg1 showed potential inhibition to the enhanced 5-HT induced current of 5-HT3A receptor by desflurane. CONCLUSIONS: Although ginsenosides have substantial inhibitory effect on 5-HT3A receptor, the effects of ginsenoside on potentiation by desflurane of 5-HT induced current via recombinant 5HT3A receptor may depend on the types of ginsenoside, which suggesting that ginsenoside might have an antagonistic action to nausea and vomiting associated with volatile anesthetics | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 681~686 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF ANESTHESIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Desflurane의 세로토닌3A형 수용체 항진작용에 대한 인삼사포닌의 효과 | - |
dc.title.alternative | Effect of ginsenosides on the desflurane modulation in the recombinant serotonin type 3A receptor expressed in Xenopus laevis oocytes. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | 최승호 | - |
dc.contributor.googleauthor | 김미경 | - |
dc.contributor.googleauthor | 구본녀 | - |
dc.contributor.googleauthor | 민경태 | - |
dc.identifier.doi | 10.4097/kjae.2009.56.6.681 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00193 | - |
dc.contributor.localId | A01400 | - |
dc.contributor.localId | A04101 | - |
dc.relation.journalcode | J01963 | - |
dc.identifier.eissn | 2005-7563 | - |
dc.subject.keyword | Desflurane | - |
dc.subject.keyword | Ginsenosides | - |
dc.subject.keyword | Serotonin type 3A receptor | - |
dc.subject.keyword | Xenopus laevis oocyte | - |
dc.contributor.alternativeName | Ku, Bon Nyo | - |
dc.contributor.alternativeName | Min, Kyeong Tae | - |
dc.contributor.alternativeName | Choi, Seung Ho | - |
dc.contributor.affiliatedAuthor | Ku, Bon Nyo | - |
dc.contributor.affiliatedAuthor | Min, Kyeong Tae | - |
dc.contributor.affiliatedAuthor | Choi, Seung Ho | - |
dc.citation.volume | 56 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 681 | - |
dc.citation.endPage | 686 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF ANESTHESIOLOGY, Vol.56(6) : 681-686, 2009 | - |
dc.identifier.rimsid | 46779 | - |
dc.type.rims | ART | - |
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