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In vitro derby imaging of cancer biomarkers using quantum dots

Authors
 Mee Hyang Ko  ;  Soonhag Kim  ;  Won Jun Kang  ;  Jung Hwan Lee  ;  Hyungu Kang  ;  Sung Hwan Moon  ;  Do Won Hwang  ;  Hae Young Ko  ;  Dong Soo Lee 
Citation
 SMALL, Vol.5(10) : 1207-1212, 2009 
Journal Title
SMALL
ISSN
 1613-6810 
Issue Date
2009
MeSH
Biomarkers, Tumor/metabolism* ; Cell Line, Tumor ; Fluorescence ; Humans ; Imaging, Three-Dimensional/methods* ; Integrin alphaVbeta3/metabolism ; Microscopy, Confocal ; Oligodeoxyribonucleotides/metabolism ; Oligopeptides/metabolism ; Phosphoproteins/metabolism ; Quantum Dots* ; RNA-Binding Proteins/metabolism
Abstract
Semiconductor quantum dots (QDs), which have broad absorption with narrow emission spectra, are useful for multiplex imaging. Here, fluorescence derby imaging using dual color QDs conjugated by the AS1411 aptamer (targeting nucleolin) and the arginine-glycine-aspartic acid (targeting the integrin alpha(v)beta(3)) in cancer cells is reported. Simultaneous fluorescence imaging of cellular distribution of nucleolin and integrin alpha(v)beta(3) using QDs enables easy monitoring of separate targets in the cancer cells and the normal healthy cells. These results suggest the feasibility of a concurrent visualization of QD-based multiple cancer biomarkers using small molecules such as aptamer or peptide ligands.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/smll.200801580/abstract
DOI
10.1002/smll.200801580
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Won Jun(강원준) ORCID logo https://orcid.org/0000-0002-2107-8160
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103978
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